{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:56:33Z","timestamp":1790891793222,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prognostic significance of cytogenetic findings at diagnosis in polycythemia vera (PV) was investigated in a retrospective series of 137 patients. Cytogenetics were normal in 117 patients (85%) and displayed a \u2212Y abnormality in five patients (7% of male patients), and other chromosomal abnormalities in 15 patients (11%). The most frequent cytogenetic anomalies were trisomy 8 (<jats:italic>n<\/jats:italic>\u2003=\u20034), trisomy 9 (<jats:italic>n<\/jats:italic>\u2003=\u20032), deletion 20q (<jats:italic>n<\/jats:italic>\u2003=\u20032) and chromosomal 1 abnormalities (<jats:italic>n<\/jats:italic>\u2003=\u20032). Parameters that were significantly associated with abnormal cytogenetics included age \u226560\u2003yr (<jats:italic>P<\/jats:italic>\u2003=\u20030.02), but not <jats:italic>JAK2<\/jats:italic>V617F allele burden, thrombosis, hemorrhage, leukemic\/fibrotic transformation, or survival. We conclude that cytogenetic anomalies occur infrequently at PV diagnosis and do not confer an adverse outcome.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.01003.x","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T09:21:34Z","timestamp":1202894494000},"page":"197-200","source":"Crossref","is-referenced-by-count":61,"title":["Cytogenetic studies at diagnosis in polycythemia vera: clinical and <i>JAK2<\/i>V617F allele burden correlates"],"prefix":"10.1111","volume":"80","author":[{"given":"Naseema","family":"Gangat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terra L.","family":"Lasho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy M.","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Knudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Pardanani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03546"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065202"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90994-X"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/347558a0"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9083"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2322"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2079"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood.V72.2.386.386","article-title":"A prospective long\u2010term cytogenetic study in polycythemia vera in relation to treatment and clinical course","volume":"72","author":"Swolin B","year":"1988","journal-title":"Blood"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61011-8"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90032-9"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3900"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90183-X"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830110105"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.01003.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.01003.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:20:39Z","timestamp":1696965639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.01003.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1600-0609.2007.01003.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.01003.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,7]]}}}