{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:27:01Z","timestamp":1778628421428,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T00:00:00Z","timestamp":1210032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of acute Epstein\u2013Barr virus (EBV) infection in which the clinical syndrome and pattern of F\u201018\u20102\u2010fluoro\u20102\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose (FDG) uptake mimicked malignant lymphoma. A 53\u2010yr\u2010old man presented with 2\u2003wk of high fevers, night sweats, sinus congestion and severe fatigue. The patient was treated for 1\u2003wk with broad\u2010spectrum antibiotics for acute sinusitis without any improvement. Persistence of fevers and presence of abnormal lymphadenopathy seen on the abdominal computed tomography (CT) were concerning lymphoma with B symptoms. FDG positron emission tomography (PET) showed avid FDG uptake in numerous abdominal\/pelvic nodes, liver, spleen and bone marrow. These findings were highly suspicious for lymphoma. Patient underwent a pelvic lymph node biopsy which showed large granular lymphocytes that were predominantly T cells. Bone marrow biopsy showed diffuse infiltration with plasmocytoid cells that were not kappa lambda restricted. Additional diagnostic workup became available showing positive EBV IgM titers and negative IgG levels indicating acute infectious mononucleosis. Lymph node biopsy stained positively with EBV\u2010encoded RNA. We concluded that patient\u2019s abnormal FDG PET was most likely secondary to acute EBV infection. After 2\u2003months, follow\u2010up FDG PET\/CT showed marked improvement in lymphadenopathy and decreased hypermetabolic activity in the liver and spleen. Other than EBV, there are many other FDG\u2010avid non\u2010malignant conditions that may lead to false\u2010positive PET scans. FDG accumulates in inflamed and infected lesions with increased glucose metabolism. This case underscores the importance of maintaining a broad differential and restricting use of PET scans for staging.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01088.x","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T10:06:50Z","timestamp":1210068410000},"page":"154-156","source":"Crossref","is-referenced-by-count":49,"title":["FDG PET\/CT findings in acute adult mononucleosis mimicking malignant lymphoma"],"prefix":"10.1111","volume":"81","author":[{"given":"Maryam B.","family":"Lustberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Aras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry R.","family":"Meisenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,18]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3381-3387.2004"},{"key":"e_1_2_4_3_2","first-page":"1279","article-title":"Epstein\u2013Barr virus infectious mononucleosis","volume":"70","author":"Ebell MH","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rti.0000187436.99137.5e"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-0397(00)00088-1"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20028"},{"key":"e_1_2_4_7_2","first-page":"1301","article-title":"High accumulation of fluorine\u201018\u2010fluorodeoxyglucose in turpentine\u2010induced inflammatory tissue","volume":"36","author":"Yamada S","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00947964"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14366-8"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14363-2"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000222675.10765.14"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.255045122"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/318480"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2008.01088.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2008.01088.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:02:45Z","timestamp":1696989765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2008.01088.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,18]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1111\/j.1600-0609.2008.01088.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2008.01088.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,18]]}}}