{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:03:43Z","timestamp":1758906223311},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> p53 mutations and high protein expression are associated with adverse prognosis in several lymphoma subtypes. Matrix metalloproteinase\u20109 (MMP\u20109) has also been found to correlate with poor survival in all lymphomas studied. The data concerning the clinical role of protein expression of p53 or gelatinases and their inhibitors in follicular lymphoma are rare. The purpose of this study was to evaluate the prognostic and clinical implications of the immunoreactive proteins p53, MMP\u20102, MMP\u20109, tissue inhibitor of matrix metalloproteinase\u20101 (TIMP\u20101) and TIMP\u20102 in follicular lymphoma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The material consisted of 67 patients with primarily non\u2010transformed follicular lymphoma. Diagnostic lymph node tissue sections of patients were stained by immunohistochemical method using specific monoclonal antibodies.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> p53 over\u2010expression was detected in 8 (12%) out of 67 cases. p53 over\u2010expression correlated with high grade (<jats:italic>P<\/jats:italic>\u2003=\u20030.011), bulky tumour (<jats:italic>P<\/jats:italic>\u2003=\u20030.031) and forthcoming transformation (<jats:italic>P<\/jats:italic>\u2003=\u20030.001). It also correlated with poor overall (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) and cause\u2010specific survival (<jats:italic>P<\/jats:italic>\u2003=\u20030.010) in multivariate analysis and had a strong inverse correlation with time to transformation (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). MMP\u20102, MMP\u20109 and TIMP\u20102 expression correlated with high grade. MMP\u20109 positivity in centroblasts correlated with good chemotherapy response (<jats:italic>P<\/jats:italic>\u2003=\u20030.019), but it was not prognostic for survival. MMP\u20102, TIMP\u20101 or TIMP\u20102 did not associate with survival, either.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In this study, p53 over\u2010expression predicted both transformation to diffuse large B\u2010cell lymphoma and poorer overall and cause\u2010specific survival of patients with follicular lymphoma. Expression of gelatinases or their inhibitors did not have any significant correlations with prognosis, although MMP\u20109 predicted a good response to first\u2010line chemotherapy.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01113.x","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T12:24:36Z","timestamp":1215519876000},"page":"289-297","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic significance of p53 and matrix metalloproteinase\u20109 expression in follicular 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