{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:17:38Z","timestamp":1760015858642},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,6]],"date-time":"2008-09-06T00:00:00Z","timestamp":1220659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Nasal natural killer (NK)\/T\u2010cell lymphoma is characterized by chemo\u2010resistance, angiodestruction, and aggressive tumor progression. Few studies exist on molecular characteristics of this disease entity.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Expression levels of major apoptosis\u2010related proteins Bcl\u20102, Bcl\u2010x, Mcl\u20101, Bax, and a proliferative marker Ki\u201067 were analyzed in 11 nasal NK\/T\u2010cell lymphoma cases by immunohistochemical methods. Nine cases were of NK\u2010cell lineage and two cases were of T\u2010cell lineage. For comparison, 12 follicular lymphoma (FL) cases and 16 diffuse large B\u2010cell lymphoma (DLBCL) cases were also studied.<\/jats:p><jats:p><jats:bold>Results and conclusions:\u2002<\/jats:bold> Bax expression was low in all nasal NK\u2010cell lymphoma cases, which constitute the major population of nasal NK\/T\u2010cell lymphoma. Bax expression in nasal NK\u2010cell lymphoma was similar to FL and significantly lower compared with DLBCL. Bcl\u20102 expression was significantly lower in nasal NK\/T\u2010cell lymphoma compared with that of FL and DLBCL. Bcl\u2010x expression was high in all three lymphomas. Two distinct Mcl\u20101 expression groups existed for nasal NK\/T\u2010cell lymphoma (6.2\u2003\u00b1\u20035.2% and 59.1\u2003\u00b1\u200312.3%, 95% CI). Ki\u201067 expression was high in nasal NK\/T\u2010cell lymphoma, and worse prognostic groups tended to express higher levels of Ki\u201067. The results suggest a combination of impaired apoptosis and aggressive proliferation in nasal NK\/T\u2010cell lymphoma, and may provide explanations for its poor prognosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01152.x","type":"journal-article","created":{"date-parts":[[2008,9,6]],"date-time":"2008-09-06T09:47:30Z","timestamp":1220694450000},"page":"39-45","source":"Crossref","is-referenced-by-count":18,"title":["Expression levels of apoptosis\u2010related proteins and Ki\u201067 in nasal NK\u200a\/\u200aT\u2010cell lymphoma"],"prefix":"10.1111","volume":"82","author":[{"given":"Hajime","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Oshimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.10.2688.2688"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<332::AID-IJC5>3.0.CO;2-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2106::AID-CNCR11>3.0.CO;2-G"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06835.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1401"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00307.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh143"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1384"},{"key":"e_1_2_6_10_2","first-page":"11","article-title":"Clinical 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