{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:42:47Z","timestamp":1790214167716,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,9,6]],"date-time":"2008-09-06T00:00:00Z","timestamp":1220659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The p300 protein shows a striking homology with cyclic\u2010AMP\u2010response\u2010element\u2010binding\u2010protein binding protein (CBP) and both proteins form a family of DNA\u2010binding transcriptional coactivators\/histone acetyltransferases. The authors, herein, report a therapy\u2010related acute myeloid leukemia with <jats:italic>MLL\u2010p300<\/jats:italic> fusion gene. Spectral karyotyping clarified that chromosome 11 is involved in complex t(1;22;11)(q44;q13;q23), and is fused to the chromosome 22, and direct sequencing revealed the fusion of exon 8 of <jats:italic>MLL<\/jats:italic> and exon 15 of <jats:italic>p300<\/jats:italic> in this case. This is only the second reported case of leukemia with an <jats:italic>MLL\u2010p300<\/jats:italic> fusion gene, and the other case with <jats:italic>MLL\u2010p300<\/jats:italic> was also a therapy\u2010related leukemia. Considering that the <jats:italic>MLL\u2010CBP<\/jats:italic> fusion gene is also found almost exclusively in therapy\u2010related leukemia, the association of <jats:italic>MLL\u2010p300<\/jats:italic> and <jats:italic>MLL\u2010CBP<\/jats:italic> with therapy\u2010related leukemia rather than <jats:italic>de novo<\/jats:italic> leukemia is thereby suggested.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01154.x","type":"journal-article","created":{"date-parts":[[2008,9,6]],"date-time":"2008-09-06T09:47:30Z","timestamp":1220694450000},"page":"475-480","source":"Crossref","is-referenced-by-count":16,"title":["A complex t(1;22;11)(q44;q13;q23) translocation causing <i>MLL\u2010p300<\/i> fusion gene in therapy\u2010related acute myeloid leukemia"],"prefix":"10.1111","volume":"81","author":[{"given":"Hiroaki","family":"Ohnishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Takita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohmei","family":"Ida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Bessho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.32.1.495"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404150"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/374081a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/73536"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207118"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.13.2363"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.12.4699"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3945"},{"key":"e_1_2_7_10_2","first-page":"535","article-title":"All patients with the t(11;16)(q23;p13.3) that involves MLL and CBP have treatment\u2010related hematologic disorders","volume":"90","author":"Rowley JD","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8732"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199709)20:1<60::AID-GCC9>3.0.CO;2-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<264::AID-GCC6>3.0.CO;2-#"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208711"},{"key":"e_1_2_7_15_2","first-page":"333","article-title":"SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24","volume":"62","author":"Ono R","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_7_16_2","first-page":"1766","article-title":"Complete exon structure of the ALL1 gene","volume":"56","author":"Rasio D","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0995-z"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20077"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10167"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.4.395"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403602"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0996-33"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<138::AID-GCC2>3.0.CO;2-2"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.9.3127"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.05025"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb03392.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2008.01154.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2008.01154.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:50:17Z","timestamp":1695970217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2008.01154.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,18]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1111\/j.1600-0609.2008.01154.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2008.01154.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,18]]}}}