{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:47:30Z","timestamp":1763444850971},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T00:00:00Z","timestamp":1221609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Osteopenia\/osteoporosis is a major component of morbidity even in young patients with \u03b2\u2010thalassaemia major. Dual energy X\u2010ray absorptiometry (DXA) is the reference method for determining bone mineral density (BMD). Quantitative ultrasound sonography (QUS) for bone measurement is a relatively new, inexpensive and radiation\u2010free method that could serve as an alternative to DXA. Our aim was to assess bone status in thalassaemic patients both with QUS and DXA and, consequently, to investigate the degree of correlation between the two methods.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010three patients (15 male and 18 female) with \u03b2\u2010thalassaemia major, regularly transfused and systematically iron\u2010chelated, participated in the study. Mean age was 22.0\u2003\u00b1\u20038.0\u2003yr (range: 6.5\u201341.0\u2003yr). All patients were evaluated with QUS at radius and tibia and had DXA scan at lumbar spine vertebrae (L2\u2013L4), whereas 20 patients were additionally assessed with DXA at the left hip (femoral neck, trochanter region and Ward\u2019s triangle).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Results were expressed as <jats:italic>Z<\/jats:italic>\u2010scores compared with sex\u2010 and age\u2010matched population. Lowest mean <jats:italic>Z<\/jats:italic>\u2010scores measured with DXA were recorded at lumbar spine and Ward\u2019s triangle (\u22121.1\u2003\u00b1\u20031.13 and \u22120.95\u2003\u00b1\u20031.07, respectively). Lowest mean QUS\u2010derived <jats:italic>Z<\/jats:italic>\u2010scores were measured at radius, statistically significant compared with <jats:italic>Z<\/jats:italic>\u2010scores measured at tibia (\u22120.6\u2003\u00b1\u20031.1 vs. 0.4\u2003\u00b1\u20031.1, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). QUS measurements at radius were significantly correlated to QUS measurements at tibia (<jats:italic>r<\/jats:italic>\u2003=\u20030.51, <jats:italic>P<\/jats:italic>\u2003=\u20030.002). The latter were correlated to BMD measured at lumbar spine (<jats:italic>r<\/jats:italic>\u2003=\u20030.516, <jats:italic>P<\/jats:italic>\u2003=\u20030.002) and at trochanter region (<jats:italic>r<\/jats:italic>\u2003=\u20030.646, <jats:italic>P<\/jats:italic>\u2003=\u20030.003). All BMD measurements at hip were significantly correlated to each other. Lumbar spine BMD was correlated to BMD at femoral neck (<jats:italic>r<\/jats:italic>\u2003=\u20030.607, <jats:italic>P<\/jats:italic>\u2003=\u20030.003) and to BMD at Ward\u2019s triangle (<jats:italic>r<\/jats:italic>\u2003=\u20030.438, <jats:italic>P<\/jats:italic>\u2003=\u20030.027). Finally, no agreement was recorded between the two methods in identifying thalassaemic patients at risk for osteoporosis (\u03ba\u2003=\u20030.203, <jats:italic>P<\/jats:italic>\u2003=\u20030.04).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Quantitative ultrasound sonography could not serve as an alternate to DXA.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01159.x","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T06:38:17Z","timestamp":1221633497000},"page":"15-21","source":"Crossref","is-referenced-by-count":11,"title":["Poor correlations between measurements of bone quality by quantitative ultrasound sonography and dual energy X\u2010ray absorptiometry in patients with \u03b2\u2010thalassaemia 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