{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:37:16Z","timestamp":1792643836475,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T00:00:00Z","timestamp":1222300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Aim of this study was to evaluate prevalence and characteristics of cholelithiasis in a large population of patients with thalassemia major (TM).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Data from 858 consecutive patients with transfusion\u2010dependent thalassemia at five major Italian centers were analyzed. In these centers, a complete abdomen ultrasonography is performed yearly after the beginning of the transfusion regimen. The role of co\u2010inheriting Gilbert\u2019s syndrome genotype was investigated studying the promoter region of the UGT1\u2010A1 gene by automated sequencing.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Thirty percent of TM patients had gallstones. The Gilbert\u2019s genotype [homozygosity for (TA)<jats:sub>7<\/jats:sub> motif at UGT1A promoter gene], influenced both the prevalence of cholelithiasis and the age at which it developed.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Cholelithiasis has a remarkable frequency and precocity in patients with TM and especially in those with (TA)<jats:sub>7<\/jats:sub>\/(TA)<jats:sub>7<\/jats:sub> UGT1\u2010A1 genotype. An early biliary ultrasonography is recommended from childhood and a closer follow\u2010up in patients with thalassemia and associated Gilbert\u2019s syndrome may be indicated.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2008.01162.x","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T14:28:18Z","timestamp":1222352898000},"page":"22-25","source":"Crossref","is-referenced-by-count":32,"title":["Cholelithiasis in thalassemia 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