{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:02:30Z","timestamp":1790917350301,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>EGLN1 and EGLN3 are members of the egg\u2010laying\u2010defective 9 (EglN) prolyl\u2010hydroxylases which during normoxia catalyse hydroxylation of the hypoxia\u2010inducible factor (HIF)\u20101\u03b1, thereby promoting its ubiquitination by a complex containing the von Hippel\u2013Lindau (VHL) tumour suppressor. EGLN3 also has pro\u2010apoptotic activity in some cell types. Analyses of a well\u2010characterised series of cases of plasma cell dyscrasias, including multiple myeloma (MM), Waldenstr\u00f6m\u2019s macroglobulinaemia (WM) and monoclonal gammopathy of undetermined significance (MGUS) surprisingly demonstrated that the CpG island of EGLN3, and not EGLN1, is frequently methylated in these disorders. Multiple myeloma patients with a methylated EGLN3 promoter showed trends towards an increased risk of death, bone lytic lesions, anaemia, advanced stage of disease and the presence of extramedullary disease. Those individuals with methylation in the EGLN3 CpG island also had significantly lower albumin levels. These data suggest that the prolyl\u2010hydroxylases may be a novel class of potential tumour suppressors in plasma cell neoplasia that warrant further investigation with regard to their potential utility as biomarkers. Moreover, we observed that EGLN3 is also methylated at high frequency in B\u2010cell lymphoma subtypes, implying that loss of EGLN3 is an important epigenetic event not only in plasma cell neoplasias but also in B\u2010cell neoplasias.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2009.01344.x","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T16:45:15Z","timestamp":1252428315000},"page":"47-51","source":"Crossref","is-referenced-by-count":39,"title":["The prolyl\u2010hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia"],"prefix":"10.1111","volume":"84","author":[{"given":"Eleftheria","family":"Hatzimichael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aggeliki","family":"Dasoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelofer","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Papoudou\u2010Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Coley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dranitsaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos L.","family":"Bourantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Stebbing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.7.5.747"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404939"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-049510"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2531"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00633-3"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc885"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc704"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.06.015"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1648608"},{"key":"e_1_2_7_12_2","first-page":"5384","article-title":"Induction of cell growth regulatory genes by p53","volume":"56","author":"Madden SL","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2009.n.047"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08R09FM"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605042"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2009.01344.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2009.01344.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:08:57Z","timestamp":1698728937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2009.01344.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,11]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1111\/j.1600-0609.2009.01344.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2009.01344.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,11]]}}}