{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:09:21Z","timestamp":1791425361505,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T00:00:00Z","timestamp":1257206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell leukemia\/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding to molecular subtypes, where poor\u2010risk patients demonstrated higher expression levels. Here, we examined the mRNA expression pattern of <jats:italic>TCL1<\/jats:italic> in 144 patients with CLL, including 67 immunoglobulin heavy\u2010chain variable (IGHV) mutated, 58 IGHV unmutated and 19 patients with IGHV3\u201021 usage. A higher <jats:italic>TCL1<\/jats:italic> expression level was detected in patients with CLL with unmutated vs. mutated IGHV genes (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.001), whereas no difference was demonstrated within the IGHV3\u201021 cohort (i.e., mutated vs. unmutated and stereotyped vs. non\u2010stereotyped complementarity determining region 3). The IGHV3\u201021 subgroup displayed high <jats:italic>TCL1<\/jats:italic> mRNA expression, differing significantly from other IGHV mutated cases (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001), although 11\/19 had mutated IGHV genes. Furthermore, high <jats:italic>TCL1<\/jats:italic> expression levels were associated with significantly shorter overall survival (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Altogether, we show that <jats:italic>TCL1<\/jats:italic> mRNA expression may predict clinical outcome in CLL and that the IGHV3\u201021 subset, regardless of mutational status, displays high <jats:italic>TCL1<\/jats:italic> expression.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2009.01369.x","type":"journal-article","created":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T14:21:23Z","timestamp":1257258083000},"page":"109-116","source":"Crossref","is-referenced-by-count":8,"title":["IGHV3\u201021 gene usage is associated with high <i>TCL1<\/i> expression in chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"84","author":[{"given":"Mahmoud 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