{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:46:11Z","timestamp":1793936771601,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Objective:<\/jats:italic>\u2002Invasive <jats:italic>Trichosporon<\/jats:italic> infection has been increasingly recognized in patients with hematologic malignancies. Our study aims to clarify the clinical characteristics of this disease and factors influencing patient prognosis. <jats:italic>Patients and methods:<\/jats:italic>\u2002We retrospectively analyzed 33 cases of <jats:italic>Trichosporon<\/jats:italic> fungemia (TF) in patients with hematologic malignancies treated at our collaborating five hospitals in Japan between 1992 and 2007. <jats:italic>Results:<\/jats:italic>\u2002The majority of these patients had acute leukemia (82%), neutropenia (85%), and a history of intensive chemotherapy (91%). TF occurred as a breakthrough infection during antifungal therapy in 30 patients (91%), 18 of whom were receiving micafungin. The surveillance cultures of most patients were negative for <jats:italic>Trichosporon<\/jats:italic>. Only a few patients exhibited elevated levels of 1,3\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucan before positive blood culture. Twenty\u2010five patients (76%) died of this infection. The resolution of infection was associated with neutrophil recovery (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.0001), absence of hyperglycemia (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.023), and azole inclusive therapy (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.031). Survival was significantly longer in patients receiving antifungal therapies containing azole than in those who did not receive azole (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.0034). <jats:italic>Conclusions:<\/jats:italic>\u2002At present, the diagnosis of invasive trichosporonosis depends on blood culture studies, and the mortality of this disease is high; however, azole therapy and control of blood glucose level, together with hematopoietic recovery could help in improving the clinical outcome. When we use antifungals lacking anti\u2010<jats:italic>Trichosporon<\/jats:italic> activity, sufficient care should be taken to prevent the development of breakthrough trichosporonosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2010.01410.x","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T15:02:22Z","timestamp":1262703742000},"page":"441-447","source":"Crossref","is-referenced-by-count":109,"title":["Fatal <i>Trichosporon<\/i> fungemia in patients with hematologic 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