{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:31:19Z","timestamp":1768419079097,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T00:00:00Z","timestamp":1268697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Background:<\/jats:italic> The strategy to apply involved\u2010field radiotherapy (IF\u2010RT) after immunochemotherapy in patients with bulky follicular lymphoma (FL) remains controversial.<\/jats:p><jats:p> <jats:italic>Patients and methods:<\/jats:italic> To evaluate the benefit of consolidating IF\u2010RT, we retrospectively analysed relapse patterns and survival of patients with bulky FL. All patients were treated within a multicenter prospective randomized trial on 126 patients with one, three or six cycles Rituximab and six cycles CHOP. According to the protocol, patients presenting with bulky disease were to undergo consolidating IF\u2010RT after immunochemotherapy. Forty\u2010two eligible patients with bulky disease were identified, of which 26 were irradiated and 16 were not, contrary to the demand of the protocol.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> There was no significant difference between the irradiated and the non\u2010irradiated group regarding presenting characteristics (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). After a median follow\u2010up of 60\u2003months, 21 patients relapsed. In the irradiated group, relapse occurred in 12 of 26 patients. Fifty percent of relapses were located within the original bulk or within the bulk plus a new location. In the non\u2010irradiated group, 9 of 16 patients relapsed. There was no statistically significant difference between exposure to IF\u2010RT and the likelihood of a relapse per se (<jats:italic>P<\/jats:italic>\u2003=\u20030.751) or at a specific location (<jats:italic>P<\/jats:italic>\u2003=\u20030.66). Six\u2010yr\u2010PFS\u2010 (<jats:italic>P<\/jats:italic>\u2003=\u20031.0) and OS\u2010rates (<jats:italic>P<\/jats:italic>\u2003=\u20030.68) were 52% and 80% after IF\u2010RT and 48% and 73% without IF\u2010RT.<\/jats:p><jats:p> <jats:italic>Conclusion:<\/jats:italic> There was no difference in relapse rate, PFS and OS between patients treated with and without consolidating IF\u2010RT. This is the first analysis of its kind conducted in the Rituximab era. However, these results are based on a relatively small cohort size and are derived from a retrospective analysis, with the limitations of such an analysis being well known.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2010.01445.x","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T10:56:47Z","timestamp":1268737007000},"page":"11-19","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcome of patients with follicular lymphoma and bulky disease after Rituximab\u2010CHOP immunochemotherapy with and without consolidating radiotherapy"],"prefix":"10.1111","volume":"85","author":[{"given":"Fabienne","family":"McClanahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hielscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Hensel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Neben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Hillengass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Herfarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Witzens\u2010Harig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"3909","article-title":"The Non\u2010Hodgkin\u2019s Lymphoma Classification Project","volume":"89","author":"A clinical evaluation of the International Lymphoma Study Group classification of non\u2010Hodgkin\u2019s lymphoma","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153189"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2499"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<441::AID-CNCR2820610306>3.0.CO;2-N"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90028-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.6.867"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00641-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971215)80:12<2273::AID-CNCR9>3.0.CO;2-V"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.4.1282"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.213"},{"key":"e_1_2_6_15_2","first-page":"B153","article-title":"The treatment of early stage, low grade non\u2010Hodgkin\u2019s lymphoma with involved field irradiation. 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