{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:05:22Z","timestamp":1778659522477,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T00:00:00Z","timestamp":1274313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Reactivation of hepatitis B virus (HBV) is less common in lymphoma patients with prior resolved HBV infection [characterized by hepatitis B surface antigen (HBsAg)\u2010negative\/hepatitis B core antibody (HBcAb)\u2010positive status] compared with chronic HBV infection (HBsAg positive) when receiving chemotherapy alone. The use of rituximab in chemotherapy regimen might increase the risk of HBV reactivation in patients with prior resolved HBV infection. However, the incidence of HBV reactivation is uncertain, and prophylactic antiviral treatment for this group of patients during rituximab\u2010containing chemotherapy is controversial. The objective of this study was to determine the incidence of HBV reactivation in HBsAg\u2010negative\/HBcAb\u2010positive patients diagnosed of diffuse large B\u2010cell lymphoma (DLBCL) and treated with CHOP\u2010like or RCHOP\u2010like regimen. In addition, this study also aims to explore the relationship of HBV reactivation and HBV serology.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients were identified using data from six university hospitals collected between January 1998 and November 2008. Four hundred and thirty\u2010seven patients with complete data were selected based on the diagnosis of CD20+ DLBCL, availability of HBV serum markers prior to initiation of chemotherapy and during the development of hepatitis, completion of at least four cycles of chemotherapy using CHOP\u2010like or RCHOP\u2010like regimen, and follow\u2010up for at least 6\u2003months after completion of treatment. The characteristics of the HBsAg\u2010negative\/HBcAb\u2010positive patients treated with CHOP\u2010like regimen were compared to those treated with RCHOP\u2010like regimen.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Eighty\u2010eight patients of the total 437 patients had pretreatment serology of prior resolved hepatitis B, with a prevalence of 20.1%. Among them, 45 patients received CHOP\u2010like regimen while 43 patients received RCHOP\u2010like regimen. Five patients developed hepatitis during treatment, two from CHOP group and three from RCHOP group. Only one patient treated with RCHOP had hepatitis associated with HBV reactivation, while the other four patients did not have evidence of HBV reactivation. Those four patients also demonstrated positive HBsAb at baseline, while the only patient who suffered from HBV reactivation had negative HBsAb status. This patient was successfully treated with antiviral medications. There were no statistically significant risk factors predictive of HBV reactivation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The present study revealed a low HBV reactivation rate of 2.3% in prior resolved hepatitis B among DLBCL patients undergoing RCHOP\u2010like therapy.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2010.01474.x","type":"journal-article","created":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T01:33:14Z","timestamp":1274491994000},"page":"243-250","source":"Crossref","is-referenced-by-count":55,"title":["Low incidence of hepatitis B virus reactivation during chemotherapy among diffuse large B\u2010cell lymphoma patients who are HBsAg\u2010negative\/\u200aHBcAb\u2010positive: a multicenter retrospective 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