{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:31:36Z","timestamp":1771648296799,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,11]],"date-time":"2011-04-11T00:00:00Z","timestamp":1302480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hundred and fifty\u2010six radiosynovectomies (RSs) were performed in 104 joints of 78 haemophilic patients diagnosed with chronic haemophilic synovitis. Mean patient age was 18\u2003yr. Previous studies on the same group of patients indicated that RS is an effective procedure for treating chronic haemophilic synovitis, which may require the performance of 1\u20133 injections (RS\u20101, RS\u20102, RS\u20103), with a 6\u2010month interval between them. Those studies also revealed that the parameters showing the greatest improvement after RS were pain and haemarthrosis, followed by the World Federation of Haemophilia (WFH) clinical score and muscle strength and range of motion. Such studies also demonstrated that the improvement achieved further to RS is independent of the patient\u2019s age, the type and severity of haemophilia, the previous haematologic treatment regime administered (on demand or prophylactic), the presence or absence of a circulating inhibitor, the patients\u2019 previous level or activity (or inactivity), the presence or absence of previous arthropathy (joint degeneration), of the isotope used (yttrium\u201090 or rhenium\u2010186) and of the appearance or otherwise of RS\u2010derived complications. In this study, we looked into the potential relationship between the type of joint treated and the degree of synovitis present with the need of one or more further RSs, and we found that the knee requires more injections than the elbow or the ankle and that the more severe synovites require a higher number of RS procedures.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01583.x","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T14:28:30Z","timestamp":1297261710000},"page":"430-435","source":"Crossref","is-referenced-by-count":28,"title":["Radiosynovectomy in patients with chronic haemophilic synovitis: when is more than one injection necessary?"],"prefix":"10.1111","volume":"86","author":[{"given":"Hortensia","family":"de la Corte\u2010Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emerito\u2010Carlos","family":"Rodriguez\u2010Merchan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Jimenez\u2010Yuste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677908989797"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00108.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01175.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01763.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199404000-00002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00107.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00109.x"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Radioactive synovectomy with Yttrium90 citrate in haemophilic synovitis: Brazilian experience","volume":"16","author":"Thomas S","year":"2010","journal-title":"Haemophilia"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470986929.ch12"},{"issue":"2","key":"e_1_2_6_11_2","first-page":"80","article-title":"The effectiveness of radioisotope synovectomy for chronic synovitis in Turkish pediatric haemophiliacs","volume":"14","author":"Alioglu B","year":"2008","journal-title":"Haemophilia"},{"issue":"2","key":"e_1_2_6_12_2","first-page":"80","article-title":"Evaluation of the efficacy of radiosynovectomy with hemophilic arthropaty","volume":"12","author":"Barrenechea E","year":"2006","journal-title":"Haemophilia"},{"issue":"2","key":"e_1_2_6_13_2","first-page":"1","article-title":"Radioisotope synovectomy with yttrium 90 and rhenium1 86 for hemophilic synovitis: 7\u2003years, 181 patients, 209 joints, 221 applications: Izmir experience","volume":"14","author":"Kavakli K","year":"2008","journal-title":"Haemophilia"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00913.x"},{"issue":"2","key":"e_1_2_6_15_2","first-page":"80","article-title":"Management of recurrent haemarthrosis with 90Yttrium synoviorthesis: Johannesburg experience","volume":"12","author":"Mahlangu J","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.1.8259416"},{"issue":"2","key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2516.2006.01203.x","article-title":"Functional limitations anddisability in patients with severe haemophilia","volume":"12","author":"Van Genderen F","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613015"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01035.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00383.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01424.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01908.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02192.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","unstructured":"De la Corte\u2010RodriguezH Rodriguez\u2010MerchanEC Jimenez\u2010YusteV.Radiosynovectomy in haemophilia:Quantification of its effectiveness through the assessment of 10 articular parameters.J Thromb Haemost2011 25th February 2011; (Epub ahead of print).","DOI":"10.1111\/j.1538-7836.2011.04246.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","unstructured":"Rodriguez\u2010MerchanEC De la Corte\u2010RodriguezH Jimenez\u2010YusteV.What patient joint and isotope characteristics influence the response to radiosynovectomy in patients with haemophilia 2010.Haemophilia2011; (In press).","DOI":"10.1111\/j.1365-2516.2011.02546.x"},{"issue":"2","key":"e_1_2_6_26_2","first-page":"80","article-title":"Radioactive synoviorthesis","volume":"12","author":"Heim M","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81737-8"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2011.01583.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2011.01583.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:16:34Z","timestamp":1697339794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2011.01583.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1600-0609.2011.01583.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01583.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,11]]}}}