{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:04:02Z","timestamp":1790949842044,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T00:00:00Z","timestamp":1300838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Patients with primary immune thrombocytopenia (ITP) commonly describe symptoms of fatigue. However, hematologists rarely consider fatigue a manifestation of ITP.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To document the prevalence of fatigue among patients with ITP and to determine the patient characteristics that are associated with fatigue.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Using a cross\u2010sectional design, we surveyed 1871 members of the UK ITP Support Association [585 (31%) responded], and 93 patients enrolled in the Oklahoma (US) ITP Registry [68 (73%) responded] with questions about their ITP and with validated symptom assessment scales for fatigue, daytime sleepiness, and orthostatic symptoms.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The prevalence of fatigue among both UK (39%) and US (22%) patients was significantly greater than expected compared with normal subjects (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001 and <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001 respectively). In univariate analysis of the combined cohorts, fatigue was associated with a platelet count &lt;100\u2003000\/\u03bcL, treatment with steroids, bleeding symptoms, presence of other medical conditions, daytime sleepiness, and orthostatic symptoms. Fatigue was not associated with age, gender, duration of ITP, or splenectomy status. Multivariate analysis of the combined cohorts was stratified for the presence or absence of bleeding symptoms. Among 107 patients with bleeding symptoms, fatigue was independently associated with a platelet count &lt;100\u2003000\/\u03bcL and female gender. Among 491 patients without bleeding symptoms, fatigue was independently associated with a platelet count &lt;30\u2003000\/\u03bcL, presence of other medical conditions, daytime sleepiness, and orthostatic symptoms.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Fatigue is a common symptom among patients with ITP. These data provide the basis for future studies to define the clinical importance of fatigue in ITP.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01587.x","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T22:17:30Z","timestamp":1297808250000},"page":"420-429","source":"Crossref","is-referenced-by-count":80,"title":["Fatigue in adult patients with primary immune thrombocytopenia"],"prefix":"10.1111","volume":"86","author":[{"given":"Julia L.","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley I.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Vesely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula H. B.","family":"Bolton\u2010Maggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdra R.","family":"Terrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.1.3.3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04131.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010501"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07717.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02175-9"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4598"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-13"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802377461"},{"key":"e_1_2_7_12_2","volume-title":"SF\u201036 Physical and Mental Health Summary Scales: A Manual for Users of Version 1","author":"Ware JE","year":"2001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20992"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07464.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32993"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.5.705"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01857.x"},{"key":"e_1_2_7_18_2","first-page":"2115","article-title":"Fatigue, rheumatoid arthritis, and anti\u2010tumor necrosis factor therapy: an investigation in 24,831 patients","volume":"11","author":"Wolfe F","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel021"},{"key":"e_1_2_7_20_2","first-page":"1407","article-title":"The prevalence and meaning of fatigue in rheumatic disease","volume":"23","author":"Wolfe F","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.5.291"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.05.003"},{"key":"e_1_2_7_23_2","first-page":"313","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"18","author":"Venables PJW","year":"2004","journal-title":"Best Pract Res Clin Haematol"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21230"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21609"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.021"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn043"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03223.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08322.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.Supplement_1.S79"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80385-2"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080317"},{"key":"e_1_2_7_33_2","first-page":"10","article-title":"Fatigue in early renal disease","volume":"14","author":"Newton JL","year":"2009","journal-title":"Br J Renal Med"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm057"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.8.703"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.4065\/80.3.330"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/4.2.103"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.777.526"},{"key":"e_1_2_7_40_2","first-page":"324","article-title":"General practitioners\u2019 experience of the chronic fatigue syndrome","volume":"41","author":"Ho\u2010Yen DO","year":"1991","journal-title":"Br J Gen Pract"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.139303"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun164"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg468"},{"key":"e_1_2_7_44_2","first-page":"1869","article-title":"Autonomic and orthostatic dysfunction in primary Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Mandl T","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_45_2","first-page":"G764","article-title":"Impaired cardiovascular function in primary biliary cirrhosis","volume":"298","author":"Newton JL","year":"2010","journal-title":"Am J Physiol (GI)"},{"key":"e_1_2_7_46_2","first-page":"608","article-title":"Impaired cardiovascular response to standing in chronic fatigue syndrome","volume":"40","author":"Hollingsworth K","year":"2010","journal-title":"EJCI"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01265.x"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01322.x"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp091"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2011.01587.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2011.01587.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:16:41Z","timestamp":1697339801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2011.01587.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,23]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1600-0609.2011.01587.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01587.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,23]]}}}