{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:12:12Z","timestamp":1765231932063},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The presence of B\u2010cell clones in 76 cases with peripheral T\u2010cell lymphoma (PTCL) and precursor T\u2010lymphoblastic lymphoma (T\u2010LBL) and its correlation with Epstein\u2013Barr virus (EBV) was studied.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> DNA was extracted from paraffin sections and\/or fresh\u2010frozen samples and then used for clonality analysis using a modified BIOMED\u20102 polymerase chain reaction (PCR)\u2010based method.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> T\u2010 and B\u2010cell clones were detected in 59 (77.6%) and 14 (18.4%) of 76 patients, respectively: 90% and 30% of cases with PTCL, not otherwise specified, 76.4% and 17.6% of cases with angioimmunoblastic T\u2010cell lymphoma, 77% and 7.6% of cases with adult T\u2010cell lymphoma, 50% and 0% of cases with anaplastic large T\u2010cell lymphoma, 62.5% and 12.5% of cases with T\u2010LBL, and 50% and 0% of cases with intestinal T\u2010cell lymphoma, respectively. Histological and immunohistochemical analyses revealed the presence of large B cells in lesional tissues, which were occasionally monoclonal. The presence of B\u2010cell clones was highly associated with EBV positivity, as revealed by <jats:italic>in situ<\/jats:italic> hybridization. In two cases that were evaluated by serial histological and molecular examination, EBV\u2010positive cells persisted in one and disappeared in the other.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These findings suggest a role for EBV in the evolution of B\u2010cell clones in T\u2010cell lymphomas.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01597.x","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T00:48:50Z","timestamp":1299026930000},"page":"412-419","source":"Crossref","is-referenced-by-count":23,"title":["Presence of B\u2010cell clones in T\u2010cell lymphoma"],"prefix":"10.1111","volume":"86","author":[{"given":"Mona 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