{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T22:25:40Z","timestamp":1767219940639,"version":"3.38.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,2]],"date-time":"2011-10-02T00:00:00Z","timestamp":1317513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trimethoprim\u2010sulfamethoxazole (TMP\/SMX) is used in children with acute lymphoblastic leukemia (ALL) to prevent Pneumocystis pneumonia (PCP). We explored to which extent TMP\/SMX influenced methotrexate (MTX)\/6\u2010mercaptopurine (6MP) dosage, myelosuppression, and event\u2010free survival (EFS) during maintenance therapy. Of 447 study patients treated by the NOPHO ALL92 protocol, 120 patients received TMP\/SMX continuously for 2\u20137\u2003d\/wk (TMP\/SMX<jats:sub>2\u20137<\/jats:sub>) and 287 patients never received TMP\/SMX (TMP\/SMX<jats:sub>never<\/jats:sub>). Ten patients (all TMP\/SMX<jats:sub>never<\/jats:sub>) developed PCP, eight of which occurred within 7\u2003months from the start of maintenance therapy. The TMP\/SMX<jats:sub>2\u20137<\/jats:sub>group received lower oral 6MP doses than TMP\/SMX<jats:sub>never<\/jats:sub>patients (50.6 vs. 63.9\u2003mg\/m<jats:sup>2<\/jats:sup>\/d;<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) but had lower absolute neutrophil counts (ANC) (median 1.7 vs. 2.0\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L;<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). In Cox multivariate analysis, higher ANC levels (<jats:italic>P<\/jats:italic>\u2003=\u20030.04) and male gender (<jats:italic>P<\/jats:italic>\u2003=\u20030.06) were related to reduced EFS. ANC had no effect on EFS among TMP\/SMX<jats:sub>2\u20137<\/jats:sub>patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.40) but did for TMP\/SMX<jats:sub>never<\/jats:sub>patients (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). The difference in the effect on EFS between TMP\/SMX<jats:sub>2\u20137<\/jats:sub>and TMP\/SMX<jats:sub>never<\/jats:sub>patients was not significant (<jats:italic>P<\/jats:italic>\u2003=\u20030.46). EFS did not differ between TMP\/SMX<jats:sub>2\u20137<\/jats:sub>and TMP\/SMX<jats:sub>never<\/jats:sub>patients (0.83 vs. 0.83;<jats:italic>P<\/jats:italic>\u2003=\u20030.82). These results suggest that TMP\/SMX is effective in preventing PCP and may have an antileukemic effect. TMP\/SMX should be given the entire duration of maintenance therapy.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01695.x","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T04:35:47Z","timestamp":1317616547000},"page":"78-86","source":"Crossref","is-referenced-by-count":24,"title":["<i>Pneumocystis jiroveci<\/i>pneumonia prophylaxis during maintenance therapy influences methotrexate\/6\u2010mercaptopurine dosing but not event\u2010free survival for childhood acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"88","author":[{"given":"Mette","family":"Levinsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Shabaneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrine","family":"Bohnstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arja","family":"Harila\u2010Saari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olafur G.","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kanerva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lindblom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bendik","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth W.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Nordic Society of Paediatric Haematology and Oncology (NOPHO)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,2]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"CD005590","article-title":"Prophylaxis for Pneumocystis pneumonia (PCP) in non\u2010HIV immunocompromised patients","author":"Green H","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2009.02.005"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.1.35"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2009.06.010"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.2.101"},{"key":"e_1_2_8_7_2","first-page":"28","article-title":"Pneumonia during therapy for childhood acute lymphoblastic leukemia","volume":"134","author":"Siegel SE","year":"1980","journal-title":"Am J Dis Child"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.9.1231"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1025353"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.9.2817"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199024000-00010"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200709050-00003"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80439-4"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254595"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870101)59:1<19::AID-CNCR2820590108>3.0.CO;2-B"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.039"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401961"},{"volume-title":"An International System for Human Cytogenetic Nomenclature","year":"1995","author":"Mitelman F","key":"e_1_2_8_18_2"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb05807.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood.V55.3.501.501","article-title":"The effect of trimethoprim\/sulfamethoxazole on Friend erythroleukemia cells","volume":"55","author":"Steinberg SE","year":"1980","journal-title":"Blood"},{"volume-title":"Nonparametric Statistics for the Behavioral Sciences","year":"1988","author":"Siegel S","key":"e_1_2_8_21_2"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4348-9"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables (with discussion)","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc B"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_8_25_2","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22719"},{"key":"e_1_2_8_27_2","first-page":"1067","volume-title":"Principles and Practice of Pediatric Oncology","author":"Freifelt AG","year":"1997"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1997.tb05781.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1157"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165480"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403783"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019209006392"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019209018324"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880018809037365"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.25"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019109028803"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00930.x"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02782.x"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22038"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2011.01695.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2011.01695.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:08:45Z","timestamp":1741774125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2011.01695.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1600-0609.2011.01695.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01695.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2011,10,2]]}}}