{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:42:10Z","timestamp":1698730930734},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:00:00Z","timestamp":1318464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives:<\/jats:italic>\u2002To describe changes in costs of managing hospitalised patients with acute myeloid leukaemia (AML) after chemotherapy in Germany over 3\u2003yr, with a special focus on prophylaxis and treatment patterns as well as resource use related to invasive fungal infections (IFI). <jats:italic>Methods:\u2002<\/jats:italic>The study was conducted as a retrospective, single\u2010centre chart review in patients with AML hospitalised for chemotherapy, neutropenia and infections after myelosuppressive chemotherapy from January 2004 to December 2006 in Germany. The following resource utilisation data were collected: inpatient stay, mechanical ventilation, parenteral feeding, diagnostics, systemic antifungal medication and cost\u2010intensive concomitant medication. Direct medical costs were calculated from hospital provider perspective. <jats:italic>Results:<\/jats:italic>\u2002A total of 471 episodes in 212 patients were included in the analysis. Occurrence of IFI decreased from 5.9% in 2004 to 1.9% in 2006. Mean (\u00b1standard deviation) hospital stay decreased from 28.7\u2003\u00b1\u200317.9\u2003d in 2004 to 22.4\u2003\u00b1\u200311.8\u2003d in 2006. From 2004 to 2006, the use of a single antifungal drug increased from 30.4% to 46.9%, whereas the use of multiple antifungal drugs decreased from 24.4% to 13.1%. The use of liposomal amphotericin B declined between 2004 and 2006 (21.4% vs. 3.8%) and caspofungin between 2005 and 2006 (19.3% vs. 8.1%). Total costs per episode declined from \u20ac19\u2003051\u2003\u00b1\u200319\u2003024 in 2004 to \u20ac13\u2003531\u2003\u00b1\u20039260 in 2006; major reductions were observed in the use of antimycotics and blood products as well as length of hospital stay. <jats:italic>Conclusion:<\/jats:italic>\u2002Analysis of real\u2010life data from one single centre in Germany demonstrated a change in antifungal management of patients with AML between 2004\/2005 and 2006, accompanied by a decline in total costs.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01704.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T04:37:31Z","timestamp":1314851851000},"page":"68-77","source":"Crossref","is-referenced-by-count":2,"title":["Antifungal management and resource use in patients with acute myeloid leukaemia after chemotherapy \u2013 retrospective analysis of changes over 3\u2003yr in a German 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