{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:54:54Z","timestamp":1778151294479,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the role of lipocalin\u20102 (LCN\u20102) and its receptor (SLC22A17) in mediating clonal dominance in a patient with both <jats:italic>BCR\u2010ABL<\/jats:italic> and <jats:italic>JAK2<\/jats:italic>\u2010V617F mutations. LCN\u20102 mRNA showed a near 50\u2010fold increase in expression, accompanied by down\u2010regulation of SLC22A17, coinciding with increase in BCR\u2010ABL transcripts, loss of <jats:italic>JAK2<\/jats:italic>\u2010V617F and change of clinical phenotype from polycythaemia vera to chronic myeloid leukaemia. These changes were reversed after commencing imatinib mesylate. Consistent with experimental studies, BCR\u2010ABL+ cells express LCN\u20102 leading to suppression of BCR\u2010ABL\u2010 cells and explain their eventual dominance when occurring together with <jats:italic>JAK2<\/jats:italic>\u2010V617F.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2011.01712.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T19:58:31Z","timestamp":1317153511000},"page":"175-178","source":"Crossref","is-referenced-by-count":5,"title":["Lipocalin\u20102 is associated with modulation of disease phenotype in a patient with concurrent <i>JAK2<\/i>\u2010V617F and <i>BCR\u2010ABL<\/i> mutation"],"prefix":"10.1111","volume":"88","author":[{"given":"Veera S.","family":"Nadarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chow\u2010Hiang","family":"Ang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping\u2010Chong","family":"Bee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,17]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01458.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0471-6"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.027"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.35"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208500"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.209"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.216549"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.118653"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.155"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707125200"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.071191"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2011.01712.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2011.01712.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T13:12:33Z","timestamp":1698757953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2011.01712.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,17]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1600-0609.2011.01712.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01712.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,17]]}}}