{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:35:00Z","timestamp":1781822100269,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Abstract<\/jats:title>Concurrent BCL<\/jats:styled-content>2 and MYC<\/jats:styled-content> translocations, so called double hit (DH<\/jats:styled-content>), are a rare finding in large B<\/jats:styled-content>\u2010cell lymphoma (LBCL<\/jats:styled-content>). Based on data from retrospective series, DH<\/jats:styled-content> has been correlated with aggressive clinical behaviour and poor outcome. We conducted a consecutive study of DH<\/jats:styled-content> incidence and correlation with pathologic and clinical characteristics, including response to Rituximab\u2010containing chemotherapy and survival, in an unselected cohort of patients with LBCL<\/jats:styled-content>. Translocations involving BCL<\/jats:styled-content>2 and MYC<\/jats:styled-content> loci were examined with fluorescent in situ<\/jats:italic> hybridization (FISH<\/jats:styled-content>) in 157 patients with diffuse large B<\/jats:styled-content>\u2010cell lymphoma (DLBCL<\/jats:styled-content>) or B<\/jats:styled-content>\u2010cell lymphoma, unclassifiable, with features intermediate between diffuse large B<\/jats:styled-content>\u2010cell lymphoma and Burkitt lymphoma (BCLU<\/jats:styled-content>). The incidence of DH<\/jats:styled-content> was 11% in the total cohort, 7% of primary LBCL<\/jats:styled-content> and 21% of transformed LBCL<\/jats:styled-content>. DH<\/jats:styled-content> lymphomas were all GCB<\/jats:styled-content> immunophenotype and were more often BCLU<\/jats:styled-content>. No clinical characteristics were correlated with the presence of DH<\/jats:styled-content>, which also had no impact on overall response rate (ORR<\/jats:styled-content>), relapse rate or overall survival (OS<\/jats:styled-content>). However, sub\u2010stratification of DH<\/jats:styled-content> lymphomas by FISH<\/jats:styled-content> indicated a possible inferior survival related to immunoglobulin MYC<\/jats:styled-content> translocation partner gene. Screening of patients with BCLU<\/jats:styled-content> and DLBCL<\/jats:styled-content> of GCB<\/jats:styled-content> type for DH BCL<\/jats:styled-content>2\/MYC<\/jats:styled-content> translocation including MYC<\/jats:styled-content> translocation partner gene may provide important prognostic information.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2012.01787.x","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T11:59:39Z","timestamp":1334663979000},"page":"63-71","source":"Crossref","is-referenced-by-count":84,"title":["Double\u2010hit BCL<\/scp>2\/MYC<\/scp> translocations in a consecutive cohort of patients with large B\u2010cell lymphoma \u2013 a single centre's experience"],"prefix":"10.1111","volume":"89","author":[{"given":"Mette \u00d8.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne O.","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Haematology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim S.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F.","family":"Lauritzen","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe L.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe O.","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Glostrup Hospital Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3874430"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171904"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V77.5.1057.1057","article-title":"MYC rearrangement and translocations involving band 8q24 in diffuse large cell lymphomas","volume":"77","author":"Ladanyi M","year":"1991","journal-title":"Blood"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3947"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404529"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-212191"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11305"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1558"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.344"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cd3aeb"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005355"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.147"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055759"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8385"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800500"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145128"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3182169948"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200015"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.73"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.7058"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.065227"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.032"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03076.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.5897"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114320"},{"key":"e_1_2_8_34_1","first-page":"431","article-title":"Pre\u2010B\u2010cell leukemia with a t(8; 14) and a t(14; 18) translocation is preceded by follicular lymphoma","volume":"2","author":"Gauwerky CE","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.3.758.758"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1309\/NKK3FEX2BE5L7EKB"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204595"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001593120"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804295105"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.230"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr058"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2012.01787.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2012.01787.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:22:56Z","timestamp":1698740576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2012.01787.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,26]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1600-0609.2012.01787.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2012.01787.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,26]]}}}