{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:34:51Z","timestamp":1791232491952,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T00:00:00Z","timestamp":1335571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is presently accepted that the <jats:italic>\n<jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content> <\/jats:italic>\n<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>816<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In this study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of indolent systemic mastocytosis. However, the <jats:italic>\n<jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content> <\/jats:italic>\n<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>816<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> mutation was detected using mutation\u2010specific <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> in both bone marrow and peripheral blood in all 25 cases, demonstrating for the first time that the <jats:italic>\n<jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content> <\/jats:italic>\n<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>816<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> mutation is consistently present in non\u2010mast cells in indolent systemic mastocytosis and that these cells are circulating in peripheral blood.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2012.01789.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T15:08:29Z","timestamp":1333465709000},"page":"42-46","source":"Crossref","is-referenced-by-count":45,"title":["Circulating <i><scp>KIT<\/scp><\/i><scp>D<\/scp>816<scp>V<\/scp> mutation\u2010positive non\u2010mast cells in peripheral blood are characteristic of indolent systemic mastocytosis"],"prefix":"10.1111","volume":"89","author":[{"given":"Thomas","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Broesby\u2010Olsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Mastocytosis Centre Odense University Hospital (MastOUH)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"54","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015545"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.003"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06619.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205237"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-078097"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085563"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2010.10.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2005.12.020"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-335950"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2012.01789.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2012.01789.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:22:59Z","timestamp":1698726179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2012.01789.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1600-0609.2012.01789.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2012.01789.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,28]]}}}