{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:44:45Z","timestamp":1761101085111},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T00:00:00Z","timestamp":1341360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Abstract<\/jats:title>Reduced\u2010intensity conditioning (RIC<\/jats:styled-content>)\u2010alloSCT<\/jats:styled-content> is increasingly used for acute myelogenous leukemia. Limited data are available for the comparison of peripheral blood stem cells with bone marrow for RIC<\/jats:styled-content>\u2010alloSCT<\/jats:styled-content>. We used the E<\/jats:styled-content>uropean G<\/jats:styled-content>roup for B<\/jats:styled-content>lood and M<\/jats:styled-content>arrow T<\/jats:styled-content>ransplantation (EBMT<\/jats:styled-content>) ALWP<\/jats:styled-content> data to compare the outcome of mobilized peripheral blood stem cells (PBSC<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a01430) vs. bone marrow (BM<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a0107) for acute myelogenous leukemia (AML<\/jats:styled-content>) patients with complete remission that underwent RIC<\/jats:styled-content>\u2010alloSCT<\/jats:styled-content> from compatible sibling donors. The leukemia features, the disease status, and the time from diagnosis were similar between the two groups. Engraftment was achieved in 99% and 93% in the PBSC<\/jats:styled-content> and BM<\/jats:styled-content> groups, respectively (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). The day of engraftment was significantly earlier for the PBSC<\/jats:styled-content> vs. the BM<\/jats:styled-content> group, 15 (1\u201359) and 19 (5\u201369), respectively (P<\/jats:italic>\u00a0<\u00a00.001). Acute GVHD<\/jats:styled-content>, severe GVHD<\/jats:styled-content> (grade III\u2013IV) and chronic GVHD<\/jats:styled-content> did not differ between the groups. leukemia\u2010free survival (LFS<\/jats:styled-content>), relapse, and non\u2010relapsed mortality (NRM<\/jats:styled-content>) were 51\u00a0\u00b1\u00a02%, 32\u00a0\u00b1\u00a01%, and 17\u00a0\u00b1\u00a01% vs. 50\u00a0\u00b1\u00a06%, 38\u00a0\u00b1\u00a06%, and 12\u00a0\u00b1\u00a03% for the PBSC<\/jats:styled-content> and BM<\/jats:styled-content> groups, respectively. Our results indicate faster engraftment, but no difference in GVHD<\/jats:styled-content>, LFS<\/jats:styled-content>, relapse, and NRM<\/jats:styled-content> when comparing PBSC<\/jats:styled-content> to BM<\/jats:styled-content> grafts from sibling donors following RIC<\/jats:styled-content> conditioning. This is the first study comparing PBSC<\/jats:styled-content> to BM<\/jats:styled-content> grafts in the RIC<\/jats:styled-content> setting, analyzing a homogeneous population of patients with AML<\/jats:styled-content> in remission. Whether PBSC<\/jats:styled-content> should be preferred for advanced phases of the disease, where the outcome is dominated by relapse incidences, needs further investigation.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2012.01811.x","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T18:35:19Z","timestamp":1338489319000},"page":"206-213","source":"Crossref","is-referenced-by-count":15,"title":["Mobilized peripheral blood stem cells compared with bone marrow from HLA<\/scp>\u2010identical siblings for reduced\u2010intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the A<\/scp>cute Leukemia W<\/scp>orking P<\/scp>arty of EBMT<\/scp>"],"prefix":"10.1111","volume":"89","author":[{"given":"Arnon","family":"Nagler","sequence":"first","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"ALWP\u2010EBMT Office, H\u00f4pital Saint\u2010Antoine AP\u2010HP, UPMC Univ Paris, UMR\u2010S 938 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avichai","family":"Shimoni","sequence":"additional","affiliation":[{"name":"Division of Hematology and Bone Marrow Transplantation Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam J.","family":"Mufti","sequence":"additional","affiliation":[{"name":"GKT School of Medicine, Department of Haematological Medicine King's College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"Cornelissen","sequence":"additional","affiliation":[{"name":"Erasmus Medical Center\/Daniel den Hoed Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de transplantation et de th\u00e9rapie cellulaire Inserm UMR 891, Institut Paoli Calmettes Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J. 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