{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:15:12Z","timestamp":1791728112833,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T00:00:00Z","timestamp":1343952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) mortality is reported to be lower in haemophilia patients than in the general population, but information on the occurrence of non\u2010fatal <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> is lacking. The aim of our study was to assess <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> history in a cohort of living haemophilia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective data on the occurrence of myocardial infarction, angina pectoris, ischaemic stroke and intracranial bleeding in 709 living <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>utch and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ritish haemophilia patients aged 30\u00a0yr or older were analysed and compared with the general age\u2010matched male population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a trend towards a lower cumulative incidence of myocardial infarction (1.7% vs. 4.0%) and ischaemic stroke (0% vs. 1.5%) in patients with severe haemophilia than in the general population, while the occurrence of angina pectoris was similar (3.2 vs. 3.7%). As expected, the cumulative incidence of intracranial bleeding was, on the other hand, significantly increased in haemophilia patients (1.6% vs. 0.4% in the general population).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest a protective effect of severe haemophilia against acute ischaemic <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0609.2012.01835.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T15:41:09Z","timestamp":1341848469000},"page":"336-339","source":"Crossref","is-referenced-by-count":36,"title":["History of non\u2010fatal cardiovascular disease in a cohort of <scp>D<\/scp>utch and <scp>B<\/scp>ritish patients with haemophilia"],"prefix":"10.1111","volume":"89","author":[{"given":"Dietje E.","family":"Fransen van de Putte","sequence":"first","affiliation":[{"name":"Van Creveldkliniek, Department of Haematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathelijn","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Department of Haematology University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makris","sequence":"additional","affiliation":[{"name":"Sheffield Haemophilia and Thrombosis Centre Royal Hallamshire Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Campbell","family":"Tait","sequence":"additional","affiliation":[{"name":"West of Scotland Haemophilia and Thrombosis Centre Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratima","family":"Chowdary","sequence":"additional","affiliation":[{"name":"Katharine Dormandy Haemophilia Centre and Thrombosis Unit Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Collins","sequence":"additional","affiliation":[{"name":"Arthur Bloom Haemophilia Centre, School of Medicine Cardiff University and University Hospital of Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Meijer","sequence":"additional","affiliation":[{"name":"Division of Haemostasis and Thrombosis, Department of Haematology University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goris","family":"Roosendaal","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Department of Haematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E. G.","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Department of Haematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline P.","family":"Mauser\u2010Bunschoten","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Department of Haematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01808.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050435"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648966"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.12.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04410.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01808.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.094232"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.238162"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2012.01835.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2012.01835.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:02:52Z","timestamp":1695488572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2012.01835.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,3]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1600-0609.2012.01835.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2012.01835.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,3]]}}}