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Recent and ongoing studies have indicated that human sebocytes express functional receptors for corticotropin\u2010releasing hormone, melanocortins, \u03b2\u2010endorphin, vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene\u2010related peptide. After ligand binding, these receptors modulate the production of inflammatory cytokines, proliferation, differentiation, lipogenesis and androgen metabolism in sebocytes. By means of their autocrine, paracrine and endocrine actions, these neuroendocrine factors appear to mediate centrally and topically induced stress towards the sebaceous gland, ultimately affecting the clinical course of acne.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2004.00254.x","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T13:28:25Z","timestamp":1098797305000},"page":"31-35","source":"Crossref","is-referenced-by-count":120,"title":["Neuroendocrine regulation of sebocytes \u2013 a pathogenetic link between stress and acne"],"prefix":"10.1111","volume":"13","author":[{"given":"Christos 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