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They differ from cell type to cell type and between cells at different locations. The major circulating androgens, dehydroepiandrosterone sulfate and androstenedione, are predominantly produced in the adrenal glands, and testosterone and 5\u03b1\u2010dihydrotestosterone are mainly synthesized in the gonads. Testosterone in women and 5\u03b1\u2010dihydrotestosterone in both genders are also synthesized in the skin. Skin cells express all androgen metabolizing enzymes required for the independent cutaneous synthesis of androgens and the development of hyperandrogenism\u2010associated conditions and diseases, such as seborrhea, acne, hirsutism and androgenetic alopecia. The major thrust of drug design for the treatment of androgen\u2010associated disorders has been directed against several levels of androgen function and metabolism. 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