{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:13:42Z","timestamp":1791249222611,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"s4","license":[{"start":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T00:00:00Z","timestamp":1098748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> It has been shown that epidermal keratinocytes have the capacity for the UVB\u2010induced photochemical conversion of 7\u2010dehydrocholesterol to vitamin D<jats:sub>3<\/jats:sub>, and also for the enzymatically controlled hydroxylation of the photolysis product. This metabolic loop results in the formation of the biologically active final product 1\u03b1,25\u2010dihydroxyvitamin D<jats:sub>3<\/jats:sub> (1\u03b1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, calcitriol). The epidermal synthesis of calcitriol is of fundamental relevance because calcitriol regulates important cellular functions in keratinocytes and immunocompetent cells. Because of their anti\u2010proliferative and prodifferentiating effects, calcitriol and other vitamin D analogs are highly efficient in the treatment of psoriasis vulgaris. In addition, the known therapeutic effect of UVB light therapy in the treatment of psoriasis may, at least in part, be mediated via UVB\u2010induced synthesis of calcitriol. Increasing evidence now indicates that cutaneous vitamin D synthesis is of great importance for the prevention of a broad variety of diseases, including various malignancies. It has been postulated that cancer mortality could be reduced via careful UV exposure or, more safely, via oral substitution with vitamin D. These new findings must be taken into account when establishing new sun protection guidelines for the prevention of skin cancer. In addition, better understanding of the metabolism of vitamin D in the skin has opened up new perspectives for the therapeutic application of vitamin D analogs, e.g. in inflammatory skin diseases.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2004.00257.x","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T13:28:25Z","timestamp":1098797305000},"page":"11-15","source":"Crossref","is-referenced-by-count":89,"title":["Vitamin D and skin: new aspects for dermatology"],"prefix":"10.1111","volume":"13","author":[{"given":"Bodo","family":"Lehmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Querings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Reichrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,26]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6251551"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(97)90006-9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90722-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112609"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01538.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0387-6"},{"key":"e_1_2_8_8_2","first-page":"583","volume-title":"Vitamin D Endocrine System: Structural, Biological, Genetic and Clinical Aspects. Proceedings of the Eleventh Workshop on Vitamin D, Nashville, TN, USA, May 27\u2013June 1, 2000","author":"Segaert S","year":"2000"},{"key":"e_1_2_8_9_2","first-page":"27","volume-title":"Abstracts of the Twelfth Workshop on Vitamin D, Maastricht, The Netherlands, July 6\u201310, 2003","author":"Vatieghem K","year":"2003"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12343866"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70320-7"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2340\/0001555577268272","article-title":"The effectiveness of topical 1,25\u2010dihydroxyvitamin D3 (1,25(OH)2D3) application in the treatment of psoriasis: an immunohistological evaluation","volume":"77","author":"Reichrath J","year":"1997","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_8_13_2","first-page":"357","volume-title":"Vitamin D. 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