{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:52:39Z","timestamp":1781139159712,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T00:00:00Z","timestamp":1235001600000},"content-version":"vor","delay-in-days":964,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Psychological factors are believed to play a role in the pathogenesis of alopecia areata (AA), a frequently encountered hair disorder. In our study, statistically significant elevation of psychological stress was felt by AA patients prior hair loss compared with control, which was strongly believed contributory to hair loss (<jats:italic>t<\/jats:italic>\u2010test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). The corticotropin\u2010releasing hormone (CRH) and proopiomelanocortin (POMC) mRNA have been identified in the basal layer of the epidermis and pilosebaceous units of the normal scalp. And with the recent discovery of melanocytes and dermal fibroblasts capable of corticosterone production, the presence of a local stress response system resembling the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis has been suggested. The local stress response system is involved in regulation of the normal hair cycle, but its precise role in AA is unknown. The influence of a local HPA axis or rather, CRH\u2013POMC axis in AA was investigated by analysing immunohistochemically the expression levels of CRH and POMC peptides, including the adrenocorticotropic hormone (ACTH) and <jats:italic>\u03b1<\/jats:italic>\u2010melanocyte\u2010stimulating hormone (<jats:italic>\u03b1<\/jats:italic>\u2010MSH), in a number of AA lesions and normal scalp (as control). The epidermis and pilosebaceous units of normal scalp stained weakly with CRH, ACTH and <jats:italic>\u03b1<\/jats:italic>\u2010MSH, whereas those from the affected sites of the AA group showed intense expression of the peptides (chi\u2010square test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). The meaning of this enhanced expression and their role in the pathogenesis of AA should be further evaluated in future.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2006.00003.x","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T02:51:28Z","timestamp":1235098288000},"page":"515-522","source":"Crossref","is-referenced-by-count":47,"title":["Immunoreactivity of corticotropin\u2010releasing hormone, adrenocorticotropic hormone and <i>\u03b1<\/i>\u2010melanocyte\u2010stimulating hormone in alopecia areata"],"prefix":"10.1111","volume":"15","author":[{"given":"Hei Sung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Ho","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baik Kee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08686.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0254fje"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb05049.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.5.457"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.2340\/0001555577296298"},{"key":"e_1_2_7_8_2","first-page":"7","article-title":"Effect of stress and other psychological factors on the pathophysiology and treatment of dermatoses","volume":"12","author":"Katsarou\u2010Katsari A","year":"1999","journal-title":"Int J Immunopathol Pharmacol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051732"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.22145.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0851"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0487fje"},{"key":"e_1_2_7_13_2","first-page":"658","article-title":"Detection of proopiomelanocortin\u2010derived antigens in normal and pathologic human skin","volume":"122","author":"Slominski A","year":"1993","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.013"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000249708"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590210048007"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3928\/0048-5713-19780801-08","article-title":"Emotionally triggered disease in a dermatologic practice","volume":"8","author":"Griesemer R D","year":"1978","journal-title":"Psychiatr Ann"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2340\/0001555572279280","article-title":"Can alopecia areata be triggered by emotional stress? An uncontrolled evaluation of 178 patients with extensive hair loss","volume":"72","author":"Van Der Steen P","year":"1992","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb02604.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1958.tb13304.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90284-4"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000287786"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03951.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00372.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247232"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0541"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.002"},{"key":"e_1_2_7_28_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2340\/00015555656466","article-title":"Increase of mast cells in the alopecia lesions of mice","volume":"65","author":"Tanii T","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00403-8"},{"key":"e_1_2_7_30_2","first-page":"834","article-title":"Local injections of corticotrophin releasing factor reduce doxorubicin\u2010induced acute inflammation in the eyelid","volume":"38","author":"McLoon L K","year":"1997","journal-title":"Invest Opthalmol Vis Sci"},{"key":"e_1_2_7_31_2","first-page":"258","article-title":"Peripheral anti\u2010inflammatory actions of corticotrophin\u2010releasing factor","volume":"172","author":"Wei E T","year":"1993","journal-title":"Ciba Found Symp"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08690.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00519.2004"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.01.014"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0850rev"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.181R001"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12612.x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06817.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2006.00003.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2006.00003.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:33:55Z","timestamp":1697067235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2006.00003.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":37,"aliases":["10.1111\/j.1600-0625.2006.00443.x"],"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1600-0625.2006.00003.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2006.00003.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}