{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:06:50Z","timestamp":1791954410199,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T00:00:00Z","timestamp":1151452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Solar ultraviolet (UV) radiation has hazardous effects on human health that are, in part, associated with its immunosuppressive effects via the induction of interleukin (IL)\u201010 production. Although IL\u201010 is produced by both T helper type 2 (Th2) cells and T\u2010regulatory type 1 (Tr1) cells, the relative contribution of either subset in UV radiation\u2010induced immunosuppression has not been established. Here, we show that T cells isolated from non\u2010treated allergic contact dermatitis (ACD) reactions, 48\u2003h following nickel challenge and propagated for 7\u201310\u2003days in the presence of IL\u20102, were mainly CD4<jats:sup>+<\/jats:sup> and produced IL\u201010, but little interferon\u2010<jats:italic>\u03b3<\/jats:italic>. A single sub\u2010erythematous solar\u2010simulated radiation (SSR) prior to antigen challenge exposure resulted in a clinical attenuation of the intensity of ACD reactions which was associated with a significant increase in both the magnitude of IL\u201010 production by skin\u2010infiltrating T cells and the frequency of IL\u201010\u2010producing Tr1 cells. Skin\u2010infiltrating T cells in SSR\u2010exposed, as well as non\u2010exposed, ACD reactions showed a perturbed T\u2010cell receptor (TCR)\u2010V<jats:italic>\u03b2<\/jats:italic> repertoire, without overexpression of a particular TCR\u2010V<jats:italic>\u03b2<\/jats:italic> gene product, indicating the presence of high frequencies of nickel non\u2010specific T cells in ACD reactions. These results show that a single sub\u2010erythematous SSR induces immunosuppression via the cutaneous infiltration of IL\u201010\u2010producing Tr1, and to a lesser extent, Th2 cells.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2006.00452.x","type":"journal-article","created":{"date-parts":[[2006,6,28]],"date-time":"2006-06-28T10:48:31Z","timestamp":1151491711000},"page":"615-624","source":"Crossref","is-referenced-by-count":13,"title":["A single sub\u2010erythematous exposure of solar\u2010simulated radiation on the elicitation phase of contact hypersensitivity induces IL\u201010\u2010producing T\u2010regulatory cells in human skin"],"prefix":"10.1111","volume":"15","author":[{"given":"Pierre 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