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We addressed the question whether the loss of tolerance in BP patients is associated with a reduction and\/or functional impairment of CD4+CD25+FOXP3+ regulatory T cells, which are essential for the active maintenance of self tolerance. The relative and absolute frequency of CD4+CD25+ and CD4+CD25<jats:sup>high<\/jats:sup> regulatory T cells in the peripheral blood of newly diagnosed, untreated patients was similar to that of healthy controls. Interestingly, more than 50% of circulating CD4+CD25<jats:sup>high<\/jats:sup> regulatory T cells from both patients as well as healthy controls expressed cutaneous lymphocyte\u2010associated antigen. Considerable numbers of FOXP3+ cells were detected in lesional skin of patients. CD4+CD25+ regulatory T cells of patients were functionally intact as assessed by their ability to suppress allogeneic as well as antigen\u2010specific T\u2010cell proliferation. These data argue against a general defect of CD4+CD25+FOXP3+ regulatory T cells in patients with BP.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2006.00522.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T16:24:27Z","timestamp":1166027067000},"page":"13-21","source":"Crossref","is-referenced-by-count":39,"title":["Frequency, function and CLA expression of CD4+CD25+FOXP3+ regulatory T cells in bullous pemphigoid"],"prefix":"10.1111","volume":"16","author":[{"given":"Anne","family":"Rensing\u2010Ehl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Gaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Bruckner\u2010Tuderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan 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