{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:12:35Z","timestamp":1792221155355,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We recently reported that the pathogenesis of pemphigus vulgaris (PV), an autoimmune blistering skin disorder, is driven by the accumulation of c\u2010Myc secondary to abrogation of plakoglobin (PG)\u2010mediated transcriptional c\u2010Myc suppression. PG knock\u2010out mouse keratinocytes express high levels of c\u2010Myc and resemble PVIgG\u2010treated wild\u2010type keratinocytes in most respects. However, they fail to accumulate nuclear c\u2010Myc and loose intercellular adhesion in response to PVIgG\u2010treatment like wild\u2010type keratinocytes. This suggested that PG is also required for propagation of the PVIgG\u2010induced events between augmented c\u2010Myc expression and acantholysis. Here, we addressed this possibility by comparing PVIgG\u2010induced changes in the desmosomal organization between wild\u2010type and PG knock\u2010out keratinocytes. We found that either bivalent PVIgG or monovalent PV\u2010Fab (known to trigger blister formation in vivo) disrupt the linear organization of all major desmosomal components along cell borders in wild\u2010type keratinocytes, simultaneously with a reduction in intercellular adhesive strength. In contrast, PV\u2010Fab failed to affect PG knock\u2010out keratinocytes while PVIgG cross\u2010linked their desmosomal cadherins without significantly affecting desmoplakin. These results identify PG as a principle effector of the PVIgG\u2010induced signals downstream of c\u2010Myc that disrupt the desmosomal plaque at the plasma membrane.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00557.x","type":"journal-article","created":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T21:20:26Z","timestamp":1179868826000},"page":"468-475","source":"Crossref","is-referenced-by-count":36,"title":["Plakoglobin\u2010dependent disruption of the desmosomal plaque in pemphigus vulgaris"],"prefix":"10.1111","volume":"16","author":[{"given":"Alain","family":"De Bruin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Caldelari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja M.","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hunziker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Wyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.1.1"},{"key":"e_1_2_7_3_2","first-page":"321","article-title":"Autoimmune diseases of domestic animals: an update","volume":"3","author":"Suter M M","year":"1998","journal-title":"Adv Vet Dermatol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.5.652"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2005.00367.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1600-0625.2006.00499_1.x","article-title":"Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just \u2018witnesses of disease\u2019","volume":"15","author":"Amagai M","year":"2006","journal-title":"Exp Dermatol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00451.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601224"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700735"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.4.823"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35043032"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506692200"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:HIJO.0000032358.51866.a2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501676102"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01703.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00192.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb01145.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02604.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512447200"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00960-4.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1998.6350295.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(96)80049-4"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb04095.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8064"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4408"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200206098"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205203062001"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.4.985"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1201-1076"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12274679"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.04.089"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00463.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780168"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23475"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319948"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501365200"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605125"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.4.495"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506119200"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006578200"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.05.009"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2007.00557.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2007.00557.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:09:38Z","timestamp":1697051378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2007.00557.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,21]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1600-0625.2007.00557.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2007.00557.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,21]]}}}