{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:34:35Z","timestamp":1753274075457},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T00:00:00Z","timestamp":1177372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold> Background:\u2002<\/jats:bold> Vitiligo is a skin disorder affected by genetic, environmental, local and endocrine factors. Endothelin\u20101, which is expressed by keratinocytes, has paracrine effects on melanocytes, influencing their homeostasis, proliferation and pigmentation. It is thought to play a role in the skin response to 311\u2010nm, narrow\u2010band ultraviolet irradiation.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the association of endothelin\u20101 gene (EDN1) polymorphisms with vitiligo in a Korean population.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> To evaluate the expression of endothelin\u20101 in cultured human keratinocytes after irradiation with narrow\u2010band ultraviolet B (NBUVB), we performed RT\u2010PCR and ELISA. In addition, we genotyped 312 vitiligo patients and 313 matched\u2010healthy controls, and compared the genotype, allele and haplotype frequencies of EDN1 polymorphisms (intron 4 G\/A, rs2071942 and exon 5 G\/T, rs5370) between the two groups, using PCR\u2010restriction fragment length polymorphism. The effects of sex, onset age, the presence of autoimmune diseases, family history and clinical type were analysed statistically.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> NBUVB induced the expression of endothelin\u20101 in cultured human keratinocytes. The genotype distributions and allele frequencies of EDN1 polymorphisms did not differ significantly between vitiligo patients and healthy controls. Moreover, the results were not related to sex, onset age, the presence of autoimmune diseases or family history. Interestingly, the haplotype frequencies of EDN1 polymorphisms differed significantly between vitiligo patients and healthy controls. When analysed according to clinical type, the haplotype frequencies in the focal and segmental clinical types differed significantly from healthy controls.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This study suggests that EDN1 is related to the development of vitiligo in the Korean population.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00561.x","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T09:52:01Z","timestamp":1178445121000},"page":"561-566","source":"Crossref","is-referenced-by-count":17,"title":["The association between endothelin\u20101 gene polymorphisms and susceptibility to vitiligo in a Korean population"],"prefix":"10.1111","volume":"16","author":[{"given":"Hyun\u2010Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pill","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Kyung","family":"Uhm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo 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