{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:05:36Z","timestamp":1784088336507,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,6,15]],"date-time":"2007-06-15T00:00:00Z","timestamp":1181865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Central or peripheral stress may induce the development of clinical inflammation in the pilosebaceous unit, leading to the development of acne lesions or to exacerbation of pre\u2010existing acne. Melanocortin peptides such as <jats:italic>\u03b1<\/jats:italic>\u2010melanocyte\u2010stimulating hormone and its receptors do not only regulate melanogenesis but can also affect non\u2010pigmentary processes, such as inflammation, apoptosis and sebogenesis. The purpose of the study was to investigate by immunohistochemistry if changes of melanocortin\u20101 receptor expression exist in acne lesions versus normal skin. In all, 33 patients with acne vulgaris and seven age\u2010matched volunteers without acne participated in the study. Skin biopsies were taken from acne\u2010involved faces, the non\u2010involved thigh skin of the same patients and from normal human skin. Melanocortin\u20101 receptor immunoreactivity was most prominently detectable in adnexal structures. Sebocytes and keratinocytes of the ductus seboglandularis of acne\u2010involved and non\u2010involved skin showed very intense melanocortin\u20101 receptor expression in contrast to less intense scattered immunoreactivity in normal skin samples. These data suggest that melanocortin\u20101 receptor is involved in the pathogenesis of acne.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00565.x","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T13:58:27Z","timestamp":1182002307000},"page":"547-552","source":"Crossref","is-referenced-by-count":44,"title":["Increased in situ expression of melanocortin\u20101 receptor in sebaceous glands of lesional skin of patients with acne vulgaris"],"prefix":"10.1111","volume":"16","author":[{"given":"Ruta","family":"Ganceviciene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Graziene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos 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