{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:34:26Z","timestamp":1773329666625,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Cytokine polymorphisms may influence both the risk of developing oral lichen planus (OLP) and the outcome of hepatitis C virus (HCV)\u2010infected patients and OLP has been frequently associated with HCV infection. The aim of the present study was to analyse whether cytokine polymorphisms may influence the susceptibility to HCV\u2010related OLP. Thirty\u2010five patients with OLP and chronic HCV infection (OLP\u2013HCV+ve) took part in the study. As controls, 44 patients with OLP but without HCV (OLP\u2013HCV\u2212ve) infection and 140 healthy donors were studied. Thirteen cytokine genes with 22 single nucleotide polymorphisms (SNP) were studied. IFN\u2010\u03b3 UTR 5644 genotype frequencies showed an increase in number of A\/T heterozygote in OLP\u2013HCV+ve patients compared with OLP\u2013HCV\u2212ve that approached the statistical significance [<jats:italic>P<\/jats:italic>\u2003=\u20030.03, <jats:italic>P\u2010<\/jats:italic>corrected (PC)\u2003=\u20030.66]. Contrarily, in OLP\u2013HCV+ve patients, the frequency of genotype \u2212308 G\/A of the TNF\u2010\u03b1 was decreased, whereas the genotype \u2212308 G\/G was increased compared with OLP\u2013HCV\u2212ve (<jats:italic>P<\/jats:italic>\u2003=\u20030.0005, PC\u2003=\u20030.011 and <jats:italic>P<\/jats:italic>\u2003=\u20030.0016, PC\u2003=\u20030.0352, respectively). OLP patients with and without HCV infection showed a different genetic cytokine background suggesting distinct pathogenetic mechanisms.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00577.x","type":"journal-article","created":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T09:37:56Z","timestamp":1186738676000},"page":"730-736","source":"Crossref","is-referenced-by-count":22,"title":["Cytokine gene polymorphisms in hepatitis C virus\u2010related oral lichen planus"],"prefix":"10.1111","volume":"16","author":[{"given":"Marco","family":"Carrozzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennia","family":"Dametto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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