{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:05:01Z","timestamp":1776355501138,"version":"3.51.2"},"reference-count":55,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>In vivo<\/jats:italic> levels of cytokines and presence of neutrophils and eosinophils in skin irritation are not well known. Our objective was to get more insight in inflammatory mediators and markers involved in single and repeated skin irritation. We sampled epidermis\u2010derived fluid using a novel technology that includes application of a negative pressure on the skin after creation of micropores in the stratum corneum by a laser. In nine volunteers, transdermal fluid was sampled after a single 4\u2010h 10% sodium lauryl sulphate exposure and a repeated 3\u2010week exposure (0.1% sodium lauryl sulphate). Twenty\u2010seven cytokines were assessed by multiplex assay, and IL\u20101\u03b1, eosinophil cationic protein and myeloperoxidase by enzyme\u2010linked immunosorbent assay. Levels of eosinophil cationic protein were increased after irritation and correlated with levels of myeloperoxidase. The levels of inflammatory mediators showed large interindividual differences in unexposed and exposed skin. Despite this variation, several mediators clearly showed increased levels: CC chemokine ligand (CCL)11, CXCL10 and vascular endothelial growth factor after both single and repeated exposure, IL\u20101\u03b1 and basic fibroblast growth factor after single exposure and interleukin\u20101 receptor antagonist (IL\u20101RA) after repeated exposure. After repeated exposure, CCL5 and the ratio IL\u20101RA\/IL\u20101\u03b1 both increased compared with single exposure. We conclude that single and repeated irritation induces differential and concerted expression of various inflammatory mediators and markers.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00628.x","type":"journal-article","created":{"date-parts":[[2007,9,16]],"date-time":"2007-09-16T05:03:04Z","timestamp":1189918984000},"page":"1032-1040","source":"Crossref","is-referenced-by-count":57,"title":["Differential cytokine expression in skin after single and repeated irritation by sodium lauryl sulphate"],"prefix":"10.1111","volume":"16","author":[{"given":"Cindy M.","family":"De Jongh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Lutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten 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