{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:28:37Z","timestamp":1791066517736,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Psoriasis, atopic dermatitis and allergic contact dermatitis are T\u2010cell\u2010mediated inflammatory skin diseases; chemokine receptors (CCR) 4 and 10 play an important role in the ligand\u2010mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion and subsequent extravasation to the sight of injury. We utilized established murine models of dinitrofluorobenzene\u2010, trimellitic acid anhydride\u2010 or oxazalone\u2010induced contact hypersensitivity, to reflect the various Th\u2010polarizations of different skin diseases, and investigated the functional effect of antibody blocking of single CCR ligands or combination therapy to block all CCR4 and CCR10 ligands. Our results indicate a greater reduction in inflammatory response \u2013 measured by oedema formation, myeloid cell and neutrophil infiltration and activity and CD3+ cell infiltration at the site of injury \u2013 with combination antibody therapy to CCR4 and CCR10 ligands versus controls, in nearly every tested condition. We conclude that blocking CCR4 and CCR10 simultaneously, or their ligands, should be beneficial in the treatment of T\u2010cell\u2010mediated skin diseases.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00630.x","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T09:42:56Z","timestamp":1192786976000},"page":"30-34","source":"Crossref","is-referenced-by-count":24,"title":["CCR4 and CCR10 ligands play additive roles in mouse contact hypersensitivity"],"prefix":"10.1111","volume":"17","author":[{"given":"Parham","family":"Mirshahpanah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Yang 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