{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:03:58Z","timestamp":1698685438416},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T00:00:00Z","timestamp":1193097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Theoretically, the immunization of experimental animals with an anti\u2010idiotype antibody may elicit antibodies that recognize epitopes like the original idiotype; this is archived via internal images. Using this strategy, we attempted to produce anti\u2010epithelial antibodies in Balb\/c mice immunized with a pemphigus anti\u2010idiotypic determinant. First, when an anti\u2010idiotype antibody was produced in rabbits by immunization with pemphigus immunoglobulin G (IgG), the anti\u2010idiotypic activity was tested successfully. The anti\u2010idiotype IgG was digested with pepsin and purified by gel filtration chromatography to obtain F(ab\u2019)<jats:sub>2<\/jats:sub> fragments, which were used to immunize Balb\/c mice. A control group was immunized with normal IgG. The experimental animals immunized with anti\u2010idiotype F(ab\u2019)<jats:sub>2<\/jats:sub> fragments developed anti\u2010epithelial antibodies in the following two months. The elicited antibodies had anti\u2010desmoglein 1 specificity. Additionally, the skin biopsies of these animals exhibited antibody deposition along intercellular spaces of epidermis, and 25% of them developed blisters. Sera and skin biopsies of control Balb\/c mice group were negative. In conclusion, the immunization with pemphigus anti\u2010idiotype antibody may elicit anti\u2010epithelial antibodies via internal images. This experimental approach can be used to understand the pathogenic mechanisms of pemphigus.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00631.x","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T22:58:59Z","timestamp":1193266739000},"page":"44-48","source":"Crossref","is-referenced-by-count":1,"title":["Production of anti\u2010epithelial antibodies and acantholysis by vaccination with an anti\u2010idiotypic antibody, mimicking desmoglein 1"],"prefix":"10.1111","volume":"17","author":[{"given":"Esperanza","family":"Avalos\u2010D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er\u00e9ndira","family":"L\u00f3pez\u2010Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Alvarado\u2010Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Herrera\u2010Esparza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.140.3572.1218"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/j.1460-2075.1982.tb01154.x","article-title":"Recurrent idiotypes and internal images","volume":"2","author":"Jerne N K","year":"1982","journal-title":"EMBO J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.3.703"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(81)90228-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8697"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061111"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1600-0625.2006.00499.x","article-title":"Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just \u201cwitnesses of disease\u201d?","volume":"15","author":"Amagai M","year":"2006","journal-title":"Exp Dermatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205203062001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06056.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.110400"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00863.x"},{"key":"e_1_2_6_13_2","first-page":"1109","article-title":"Complement\u2010fixing antibodies to dsDNA detected by the immunofluorescence technique on Crithidia luciliae. A critical appraisal","volume":"12","author":"Herrera\u2010Esparza R","year":"1985","journal-title":"J Rheumatol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02541.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23438.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476347"},{"key":"e_1_2_6_19_2","first-page":"418","article-title":"Production of anti\u2010idiotype antibodies in pemphigus","volume":"109","author":"Richard C","year":"1997","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1998.0818"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0769-2625(88)90056-6"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1003"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl357"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2007.00631.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2007.00631.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:04:52Z","timestamp":1697018692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2007.00631.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,23]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1600-0625.2007.00631.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2007.00631.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,23]]}}}