{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:16:28Z","timestamp":1790014588881,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> For the localization of drugs and related functional characterization, cellular\u2013subcellular resolution can be achieved with radiolabelled compounds of high specific activity and receptor microscopic autoradiography, which is the method of choice for high\u2010resolution qualitative and quantitative imaging. Detailed information together with integrative surveys can be obtained which is impossible with other methods. The history of discoveries of drug targets testifies to the utility and potential of receptor microscopic autoradiography that was designed to preserve <jats:italic>in vivo<\/jats:italic> conditions by excluding any liquid treatment during tissue preparation and to avoid translocation and loss of diffusible compounds. Examples of autoradiograms include <jats:italic>in vivo<\/jats:italic> applications of <jats:sup>3<\/jats:sup>H\u2010vitamin D, <jats:sup>3<\/jats:sup>H\u2010OCT (oxacalcitriol), <jats:sup>3<\/jats:sup>H\u2010oestradiol and <jats:sup>3<\/jats:sup>H\u2010retinoic acid. For topical applications, routes of delivery and sites of deposition and retention are demonstrated.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00636.x","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T10:18:55Z","timestamp":1194085135000},"page":"133-138","source":"Crossref","is-referenced-by-count":6,"title":["Skin research and drug localization with receptor microscopic autoradiography"],"prefix":"10.1111","volume":"17","author":[{"given":"Walter E.","family":"Stumpf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Juergen","family":"Bidmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Drug Localization in Tissues and Cells","author":"Stumpf W E","year":"2003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01927732"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01105082"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.505004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2004.03.012"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.04.012"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804601203"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572897"},{"key":"e_1_2_5_10_2","first-page":"477","article-title":"Hair follicle expression of 1,25\u2010dihydroxyvitamin D3 receptors during the murine hair cycle","volume":"13","author":"Reichrath J","year":"1994","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(96)80231-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01464331"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.06.006"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth819"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.11.025"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124618"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.10.003"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00567a032"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2003.00183.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01134449"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505223"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219863"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00737227"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2007.00636.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2007.00636.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:31:07Z","timestamp":1697031067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2007.00636.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1600-0625.2007.00636.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2007.00636.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,2]]}}}