{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:34:26Z","timestamp":1789846466873,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>The activation of receptor complexes containing glycoprotein 130 (gp130) identifies the interleukin (IL)\u20106 cytokine family. We examined members of this family for their expression and activity in hair follicles. Quantitative polymerase chain reaction using mRNA derived from microdissected, anagen\u2010stage human hair follicles and comparison to non\u2010follicular skin epithelium revealed higher levels of IL\u20106 (15.5\u2010fold) and oncostatin M (OSM, 3.4\u2010fold) in hair follicles. In contrast, expression of all mRNAs coding for IL\u20106 cytokine family receptors was reduced. Immunohistology suggested expression of OSM, gp130, leukaemia inhibitory factor receptor (LIFr) and IL\u201011r in the hair follicle root sheaths and dermal papilla, while IL\u201011, IL\u20106r and OSMr were expressed in root sheaths alone. IL\u20106 was expressed in the dermal papilla while cardiotrophin\u20101 (CT\u20101) and LIF were not observed. OSM and to a lesser extent CT\u20101 exhibited a dose\u2010dependent growth inhibition capacity on human hair follicles<jats:italic>in vitro<\/jats:italic>. OSM and CT\u20101 incubated with agarose beads and injected subcutaneously at 1\u2003\u03bcg per mouse into telogen skin of 65\u2010day\u2010old mice revealed no capacity to induce anagen hair growth. In contrast, injection of 65\u2010day\u2010old mice in which anagen had been induced by hair plucking revealed a moderate hair growth inhibitory capacity for OSM, but no significant effect for CT\u20101. The data identify OSM as a modulator of hair follicle growth and suggest other family members may also have some degree of hair growth inhibitory effect. In principle, increased expression of some IL\u20106 cytokine family members in cutaneous inflammation might contribute to the promotion of hair loss.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00643.x","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T10:18:55Z","timestamp":1194085135000},"page":"12-19","source":"Crossref","is-referenced-by-count":48,"title":["Interleukin\u20106 cytokine family member oncostatin M is a hair\u2010follicle\u2010expressed factor with hair growth inhibitory properties"],"prefix":"10.1111","volume":"17","author":[{"given":"Mei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Kissling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Freyschmidt\u2010Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"McElwee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"286","article-title":"Dinosaur\u2019s feather and chicken\u2019s tooth? 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