{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:40:35Z","timestamp":1780717235812,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Proteinase\u2010activated receptor 2 (PAR\u20102) has been shown to elicit secretion in a variety of secretory epithelial cells by the transepithelial movement of chloride ions across the apical membrane. However, it is not known whether these receptors are present and\/or functional in the secretory epithelial cells of the human eccrine sweat gland. To investigate this possibility mRNA analysis, Ca<jats:sup>2+<\/jats:sup> microspectrofluorimetry and the short circuit current (Isc) technique were used to quantify electrolyte transport in a cell line (NCL\u2010SG3) derived from human eccrine sweat gland secretory epithelia. The results provided molecular and functional evidence of the presence of PAR\u20102 receptors in the NCL\u2010SG3 cells and show that these receptors can activate transepithelial Cl<jats:sup>\u2212<\/jats:sup> secretion possibly via Ca<jats:sup>2+<\/jats:sup>\u2010activated Cl<jats:sup>\u2212<\/jats:sup> channels.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00659.x","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T02:08:08Z","timestamp":1210212488000},"page":"505-511","source":"Crossref","is-referenced-by-count":13,"title":["Activation of chloride secretion via proteinase\u2010activated receptor 2 in a human eccrine sweat gland cell line \u2013 NCL\u2010SG3"],"prefix":"10.1111","volume":"17","author":[{"given":"Douglas L.","family":"Bovell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Santic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Corbett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.274.6.C1429"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.4043"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9208"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549804600204"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/18223"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3141009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00383.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00137.2001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00342.2004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.113092"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703274"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FMJ04005X4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00464.2005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1096\/fj.04-2469fje","article-title":"Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR\u20102)","volume":"19","author":"Kunzelmann K","year":"2005","journal-title":"FASEB J"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:36:2-3:209"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00003.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013159"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0357"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1958.31"},{"key":"e_1_2_6_21_2","first-page":"391","article-title":"Update on pharmacology of the eccrine sweat gland. 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