{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:20:39Z","timestamp":1791829239076,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T00:00:00Z","timestamp":1203897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Chronic exposure to sunlight [ultraviolet light B (UVB) irradiation] is the most common cause of non\u2010melanoma skin tumors. In the present study, we investigated the effects of passive cigarette smoke superimposed over UVB irradiation, on tumor development, skin pathology and matrix changes in SKH\u20101 hairless mice. Groups of mice were exposed to 0.1\u2003J\/cm<jats:sup>2<\/jats:sup> of UVB five times per week for 20\u2003weeks and\/or exposure to passive cigarette smoke from 40 cigarettes a day over the same time period. UVB exposure resulted in an average of four large squamous cell carcinomas (SCC) and 15 smaller papillomas per mouse, whereas exposing the mice to both UVB\u2003+\u2003passive cigarette smoke completely prevented SCC formation and averaged less than one small papilloma per mouse. Oxidative DNA damage was investigated and there were no significant changes in the levels of urinary DNA adducts between control, smoke, UV and UV\u2003+\u2003smoke groups with the exception of 8\u2010oxo guanine which was significantly reduced in the presence of passive cigarette smoke. Immunohistochemistry results revealed that tumor necrosis factor receptor 2 (TNF\u2010R2), glycogen synthase kinase\u20103 beta, nuclear factor kappa B (NF\u2010\u03baB)\/p65, KI\u201067 and cyclooxygenase 2 (COX\u20102) were markedly up\u2010regulated in the epithelium by UVB exposure, whereas passive smoke exposure combined with the UVB irradiation completely blocked the expression of these proteins. Our results suggest that passive smoke exposure prevents UVB\u2010induced SCC in mice and dramatically reduces the incidence of non\u2010malignant papillomas by altering the NF\u2010\u03baB signalling pathway of tumorogenesis.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2007.00685.x","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T04:26:50Z","timestamp":1204000010000},"page":"780-787","source":"Crossref","is-referenced-by-count":10,"title":["Passive cigarette smoke exposure inhibits ultraviolet light B\u2010induced skin tumors in SKH\u20101 hairless mice by blocking the nuclear factor kappa B signalling pathway"],"prefix":"10.1111","volume":"17","author":[{"given":"Koteswara R.","family":"Gottipati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Starcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272307"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb08452.x"},{"key":"e_1_2_7_4_2","first-page":"919","article-title":"Photoimmunology","volume":"52","author":"Kriplke M L","year":"1990","journal-title":"Photochem Photobiol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb02410.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/3432321"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.11.6992"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90623-J"},{"key":"e_1_2_7_9_2","first-page":"333","article-title":"Dockery and Dimitrios Trichopoulos. 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