{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:37:02Z","timestamp":1773290222147,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T00:00:00Z","timestamp":1204243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Patients with vitiligo have low levels\/activities of catalase in their lesional and non\u2010lesional epidermis as well as in their epidermal melanocytes under <jats:italic>in vitro<\/jats:italic> conditions while the levels of catalase mRNA are unaltered. This defect leads to a build\u2010up of hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) in the 10<jats:sup>\u22123<\/jats:sup>\u2003<jats:sc>m<\/jats:sc> range in the epidermis of these patients. In this context, it was realized that 10<jats:sup>\u22123<\/jats:sup>\u2003<jats:sc>m<\/jats:sc> H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> deactivates catalase. Along this line, it was also suspected that catalase in patients with vitiligo possesses a special sensitivity to this reactive oxygen species (ROS), and indeed several heterozygous single nucleotide polymorphisms (SNPs) have been documented in the <jats:italic>cat<\/jats:italic> gene of these patients. Based on the 3D structure of human catalase monomer, we have modelled the influence of three selected SNPs on the enzyme active site, on the NADPH\u2010 as well as the tetramerization\u2010binding domains. Our results show that these SNPs severely alter catalase structurally, which in turn should make the enzyme more susceptible to ROS compared with wild\u2010type enzyme. Taken together, the work presented herein together with the earlier results on SNPs in the <jats:italic>cat<\/jats:italic> gene suggests a genetic predisposition for an altered catalase in patients with vitiligo.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00699.x","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T10:23:56Z","timestamp":1204280636000},"page":"366-371","source":"Crossref","is-referenced-by-count":22,"title":["Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH\u2010binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with vitiligo?"],"prefix":"10.1111","volume":"17","author":[{"given":"John M.","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas C. J.","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaven","family":"Chavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin U.","family":"Schallreuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3458"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12492612"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12335801"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640189"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3692.72"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700612"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.04.010"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.218"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700538"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1317"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.00057.x"},{"key":"e_1_2_5_13_2","volume-title":"Genetic association of catalase and antigen processing genes with vitiligo susceptibility","author":"Casp C B","year":"2003"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.063"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2006.00423.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03238-4"},{"key":"e_1_2_5_17_2","first-page":"526","article-title":"Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes","volume":"44","author":"Shajil E M","year":"2006","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.26928"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.30299"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00406.x"},{"key":"e_1_2_5_21_2","article-title":"Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?","author":"Schallreuter K U","year":"2008","journal-title":"Exp Dermatol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01459.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22230.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701100"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2008.00699.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2008.00699.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T10:52:52Z","timestamp":1697021572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2008.00699.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,29]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1600-0625.2008.00699.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2008.00699.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,29]]}}}