{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:09:33Z","timestamp":1791158973695,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T00:00:00Z","timestamp":1209859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    Destruction of collagen is a hallmark of photoaging. The major enzyme responsible for collagen 1 digestion, matrix metalloproteinase\u20101 (MMP\u20101), is induced by exposure to sunlight. To study the molecular trigger for this induction, human skin was ultraviolet\u2010B (UVB)\u2010irradiated and treated with liposome\u2010encapsulated DNA repair enzymes. The photolyase\u2010mediated DNA repair of epidermal UV damage was associated with a reduction of MMP\u20101 mRNA and protein expression in both the epidermal and dermal compartments of the skin. The role of the epidermal cells in MMP\u20101 induction in the fibroblasts was examined when human epidermal keratinocytes were irradiated with UVB and their media were transferred to unirradiated human dermal fibroblasts. Transfer of media from irradiated keratinocytes to unirradiated fibroblasts enhanced MMP\u20101 mRNA and protein. Thus, UV damage to keratinocytes of the epidermis may participate in the destruction of collagen in the dermis by release of soluble mediators that signal fibroblasts to release MMP\u20101. The MMP\u20101 induction was reduced when the keratinocytes were treated with DNA repair enzymes T4 endonuclease V or UV endonuclease prior to transfer of the media to fibroblasts. This implies that UVB, which deposits most of its energy on the chromatin of the epidermal keratinocytes and to a lesser extent in the upper dermis, has a significant role in photoaging. DNA damage in the keratinocytes initiates one of the signals for MMP\u20101 release, and enhancing DNA repair can reduce MMP\u20101 expression in human skin cells and tissue.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00747.x","type":"journal-article","created":{"date-parts":[[2008,5,5]],"date-time":"2008-05-05T02:27:23Z","timestamp":1209954443000},"page":"1037-1044","source":"Crossref","is-referenced-by-count":181,"title":["UV\u2010induced DNA damage initiates release of MMP\u20101 in human skin"],"prefix":"10.1111","volume":"17","author":[{"given":"Kelly K.","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niusha","family":"Damaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie D.","family":"Picart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli G.","family":"Markova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Obayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Grether\u2010Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Smiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Yarosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/379335a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2001)0730657IOMFMM2.0.CO2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372003"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2004.tb09861.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2004.tb01266.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-001-0271-1"},{"key":"e_1_2_6_8_2","first-page":"7156","article-title":"Activation of fibroblast collagenase\u20101 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen\u2010activated protein kinase and c\u2010Jun NH2\u2010terminal kinase 2","volume":"60","author":"Westermarck J","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23765.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/44188"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00210.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(02)00136-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00215-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb09091.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10354"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00093.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.11.5169"},{"key":"e_1_2_6_18_2","first-page":"287","article-title":"DNA repair liposomes in antimutagenesis","volume":"16","author":"Kibitel J","year":"1997","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030528897"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12395551"},{"key":"e_1_2_6_21_2","unstructured":"YaroshD.Purification and administration of DNA repair enzymes. 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