{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:23:44Z","timestamp":1789201424619,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Vitiligo is an acquired pigmentary disorder and its pathogenesis remains unclear. Oxidative stress is considered to be the initial pathogenic event in the melanocyte destruction. NF\u2010E2\u2010related factor2 (Nrf2) is a transcription factor regulating the expression of detoxifying and antioxidant genes. To investigate the association of the <jats:italic>Nrf2<\/jats:italic> gene promoter polymorphisms with vitiligo in Chinese Han population, the genotypes of \u2013686A\/G, \u2013684G\/A and \u2013650C\/A and the genotyping of variable number of tandem repeat were detected. The data were analysed by the chi\u2010square test and the risk was evaluated by calculating OR and 95%\u2003CI. There was statistically significant difference in genotypic and allelic frequencies of \u2013650C\/A between the two groups (<jats:italic>P\u2003&lt;\u2003<\/jats:italic>0.05). A<jats:sup>\u2212650<\/jats:sup> allele was significantly associated with the risk for vitiligo (OR\u2003=\u20031.724, \u03c7<jats:sup>2<\/jats:sup>\u2003=\u200318.096). Polymorphism of the <jats:italic>Nrf2<\/jats:italic> gene promoter at \u2013650C\/A was associated with the development of vitiligo and A<jats:sup>\u2212650<\/jats:sup> allele may be one of the risk factors.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00752.x","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T08:36:51Z","timestamp":1212568611000},"page":"1059-1062","source":"Crossref","is-referenced-by-count":60,"title":["The susceptibility to vitiligo is associated with NF\u2010E2\u2010related factor2 (<i>Nrf2<\/i>) gene polymorphisms: a study on Chinese Han 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