{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:55:04Z","timestamp":1761310504461},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> In this study, we assessed the role of melanocortin\u20101 receptor (MC1R) and agouti signalling protein (ASIP) polymorphisms in cutaneous melanoma and basal cell carcinoma (BCC) development in a Polish population. We enrolled 108 patients with skin malignant melanoma (MM) and 102 patients with BCC. The control group consisted of 93 non\u2010red haired patients, without history of skin cancers and 30 healthy individuals with red hair colour (RHC) phenotype. The complete MC1R exon was sequenced and the A8818G polymorphism of the ASIP gene was analysed using the SnaPshot protocol. Selected MC1R mutations were additionally examined using a convenient minisequencing assay. The study confirmed the important role of MC1R R variants in determining physiological variation in hair and skin colour. Our data show that individuals with R mutations had a 3.7\u2010fold increase in melanoma risk and a 3.3\u2010fold increase in BCC risk. Especially, variant R151C significantly increased the risk of both MM and BCC. The studied ASIP polymorphism was found not to be associated with MM or BCC. Stratified analysis showed that the association between MC1R mutations and the risk of MM and BCC was not significantly influenced by subjects\u2019 pigmentation characteristics or the 8818G ASIP variant. Further research is necessary, especially involving analysis of interactions between variation in MC1R and other genes, to find out if analysis of MC1R polymorphisms could be of any importance for skin cancer prevention.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00760.x","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T02:08:36Z","timestamp":1215742116000},"page":"167-174","source":"Crossref","is-referenced-by-count":28,"title":["The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A&gt;G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population"],"prefix":"10.1111","volume":"18","author":[{"given":"Urszula","family":"Brudnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Branicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wojas\u2010Pelc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Kanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200209000-00001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01196.x"},{"key":"e_1_2_5_5_2","volume-title":"Skin Melanoma in Adults","author":"Ruka W","year":"2005"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11360"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09779-9"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00002-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<348::AID-CNCR20>3.0.CO;2-X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200505000-00002"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97931-6_56"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.17.2531"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-328"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.021"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00582.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130303.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12285496"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2005.41.3.892524"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00233.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12292572"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.00039.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/302711"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01421.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/339076"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1251-2"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/319500"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9253"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji176"},{"key":"e_1_2_5_29_2","volume-title":"Molecular Cloning: A laboratory manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2006.00361.x"},{"key":"e_1_2_5_31_2","first-page":"37","article-title":"Forensic application of a rapid test for red hair colour prediction and sex determination","volume":"69","author":"Branicki W","year":"2007","journal-title":"Problems Forensic Sci"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb03199.x"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1634"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.12.894"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.104687"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22243.x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02142.x"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00287.x"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00252.x"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.10.1663"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700292"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.011536"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh120"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2007.10.003"},{"key":"e_1_2_5_45_2","first-page":"115","article-title":"Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation","volume":"1","author":"Scott M C","year":"2002","journal-title":"J Cell Sci"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01224.x"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1086\/323412"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06353.x"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30037"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2008.00760.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2008.00760.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:36:55Z","timestamp":1696988215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2008.00760.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,12]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1111\/j.1600-0625.2008.00760.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2008.00760.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,12]]}}}