{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:14:21Z","timestamp":1785392061671,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T00:00:00Z","timestamp":1216252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Photodynamic therapy (PDT) is increasingly used for the treatment of actinic keratosis (AK).<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To investigate both the efficacy of different application times and the safety of a novel patch (PD P 506 A) containing aminolaevulinic acid in the PDT of mild to moderate AK.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Applications of PD P 506 A for 0.5, 1, 2 and 4\u2003h were compared in a multicentre, randomized, blinded\u2010observer, parallel\u2010group study. After patch removal, study lesions were illuminated with red light (<jats:italic>\u03bb<\/jats:italic><jats:sub>em<\/jats:sub>\u2003\u2248\u2003630\u2003nm; 37\u2003J\/cm<jats:sup>2<\/jats:sup>). Study lesions were not pretreated (e.g. by curettage) prior to PDT. Efficacy was evaluated 4 and 8\u2003weeks after treatment. Safety and tolerability were determined through laboratory analyses and documentation of both local reactions and adverse events.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 149 patients were initially enrolled. Of these, 140 patients (520 lesions) completed the study according to protocol. Eight weeks after treatment, 86% of the AK lesions (74% of the patients) treated with 4\u2010h patch application showed complete clearance. The complete clearance rates of lesions (patients) for the 2\u2010, 1\u2010 and 0.5\u2010h treatment arms were 73% (47%), 72% (50%) and 51% (24%), respectively. Statistically, the 4\u2010h application was identified as the \u2018best treatment\u2019. Patients with clearance seemed to experience local reactions to a greater extent than patients without clearance. Local reactions to study treatments did not exceed the expected range.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The results of this first clinical efficacy study suggest excellent therapeutic outcomes with a single PD P 506 A PDT with a 4\u2010h application.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00770.x","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T07:06:03Z","timestamp":1216278363000},"page":"116-121","source":"Crossref","is-referenced-by-count":37,"title":["Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self\u2010adhesive 5\u2010aminolaevulinic acid patch"],"prefix":"10.1111","volume":"18","author":[{"given":"Axel","family":"Hauschild","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eggert","family":"Stockfleth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Gustav","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Imberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Itschert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Neuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Frambach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gollnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Brunnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ortland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Karrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,12]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"599","article-title":"Guideline Subcommittee of the European Dermatology Forum. 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