{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:55:51Z","timestamp":1774608951660,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T00:00:00Z","timestamp":1221696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction:\u2002<\/jats:bold> The aetiology of mycosis fungoides and parapsoriasis (which may be considered as an early stage of mycosis fungoides) remains debated. Previous recent studies have suspected the involvement of viral agents and particularly human herpes viruses (HHV).The aim of the present study was to screen for the presence of HHV\u20106 and HHV\u20108 genome in parapsoriasis samples.<\/jats:p><jats:p><jats:bold>Method:\u2002<\/jats:bold> Fifty paraffin\u2010embedded samples from skin biopsies of parapsoriasis were retrospectively collected from archival files in our Dermatology department. Total DNA was extracted from samples using the phenol\u2013chloroform method and the presence of viral genomes was screened using real\u2010time PCR.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Forty nine out of the fifty tissue samples of parapsoriasis were interpretable, they were all found negative for HHV\u20106 and HHV\u20108.<\/jats:p><jats:p><jats:bold>Discussion:\u2002<\/jats:bold> This study does not confirm the suspected role of HHV\u20106 or \u20108 in parapsoriasis. HHV\u20108 has been the most studied virus in parapsoriasis and more widely in cutaneous lymphoproliferative diseases and our results are in agreement with most of the studies which found none or few HHV\u20108 in more advanced stages of cutaneous lymphoproliferative diseases. Concerning HHV\u20106, our study is the first one investigating the presence of this virus in lesional tissue samples of patients with parapsoriasis. In conclusion, parapsoriasis does not seem to be associated with either HHV\u20106 or HHV\u20108.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00787.x","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T09:58:12Z","timestamp":1221731892000},"page":"357-361","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the role of human herpes virus 6 and 8 in 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