{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:37:15Z","timestamp":1789609035610,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T00:00:00Z","timestamp":1236297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>In vivo<\/jats:italic> reflectance confocal microscopy (RCM) represents a promising imaging tool that allows a non\u2010invasive examination of skin morphology in real time at nearly histological resolution, showing microanatomical structures and individual cells.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The aim of our study was to evaluate the diagnostic accuracy of confocal examination of erythematosquamous skin diseases, to define typical RCM\u2010features and assess them for their presence or absence, diagnostic performance and reliability.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three independent observers received standardized instructions about diagnostic RCM\u2010features of erythematosquamous skin diseases. A total of 1700 RCM images obtained from 75 patients with psoriasis, contact dermatitis, mycosis fungoides, chronic discoid lupus erythematosus (CDLE) or subacute cutaneous lupus erythematosus (SCLE) and from 10 \u2018healthy adults\u2019 without any skin disease were evaluated by each observer.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Overall, sensitivity and specificity values as observed by three observers were, respectively, 89.13% and 95.41% for psoriasis; 83.33% and 92.31% for contact dermatitis; 62.96% and 94.53% for SCLE\/CDLE; and 63.33% and 92.89% for mycosis fungoides.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Reflectance confocal microscopy examination appears to be a promising method for non\u2010invasive assessment of erythematosquamous skin diseases. This study provides a set of well\u2010described morphological criteria with obvious diagnostic impact, which should be used in further investigations.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2008.00822.x","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T07:25:25Z","timestamp":1236324325000},"page":"536-540","source":"Crossref","is-referenced-by-count":61,"title":["<i>In vivo<\/i> reflectance confocal microscopy of erythematosquamous skin diseases"],"prefix":"10.1111","volume":"18","author":[{"given":"Silvia","family":"Koller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Gerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Ahlgrimm\u2010Siess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Weger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Smolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hofmann\u2010Wellenhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23813.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124690"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1096"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1127"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08389.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00604.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-752x.2001.10297.x"},{"key":"e_1_2_6_9_2","first-page":"337","article-title":"Characterization of psoriasis in vivo by reflectance confocal microscopy","volume":"30","author":"Gonzalez S","year":"1999","journal-title":"J Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.026"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70151-9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.220"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.08.005"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23605.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.02.026"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07808.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23569.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21910"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2008.00822.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2008.00822.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T23:42:57Z","timestamp":1695944577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2008.00822.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,20]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1111\/j.1600-0625.2008.00822.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2008.00822.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,20]]}}}