{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:28:30Z","timestamp":1791052110804,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Skin barrier damage induces various harmful or even protective reactions in the skin, as represented by enhancement of keratinocyte cytokine production. To investigate whether acute removal of stratum corneum modulates the production of chemokines by epidermal cells, we treated ears of BALB\/c and C57BL\/6 mice by tape\u2010stripping, or acetone\u2010rubbing as a control of acute barrier disruption procedure. There was no difference between the tape\u2010stripped and acetone\u2010rubbed skin sites in the increased and recovered levels of transepidermal water loss. The mRNA expression levels of all the chemokines tested, including Th1 chemokines (CXCL10, CXCL9 and CXCL11), Th2 chemokines (CCL17 and CCL22) and eosinophil chemoattractant (CCL5), were higher in the epidermal cells from BALB\/c than in those of C57BL\/6 mice. In particular, CCL17, CCL22 and CCL5 were remarkably elevated in BALB\/c mice and augmented by tape\u2010stripping more markedly than acetone\u2010rubbing, whereas Th1 chemokines were enhanced by acetone\u2010rubbing more remarkably. Tape\u2010stripping induced dermal infiltration of eosinophils in BALB\/c but not C57BL\/6 mice. In a contact hypersensitivity model, where BALB\/c mice were sensitized on the abdomen and challenged on the ears with fluorescein isothiocyanate, mice exhibited higher ear swelling responses at the late\u2010phase as well as delayed\u2010type reactions, when challenged <jats:italic>via<\/jats:italic> the tape\u2010stripped skin. The challenge <jats:italic>via<\/jats:italic> tape\u2010stripped skin augmented the expression of IL\u20104 and CCR4 in the skin homogenated samples, indicating infiltration of Th2 cells. These findings suggest that acute barrier removal induces the expression of Th2 and eosinophil chemokines by epidermal cells and easily evokes the late phase reaction upon challenge with antigen.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2009.00899.x","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T05:26:40Z","timestamp":1245821200000},"page":"1036-1043","source":"Crossref","is-referenced-by-count":72,"title":["Induction of eosinophil\u2010 and Th2\u2010attracting epidermal chemokines and cutaneous late\u2010phase reaction in tape\u2010stripped skin"],"prefix":"10.1111","volume":"18","author":[{"given":"Ayako","family":"Onoue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,19]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.042"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319282"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0060-9"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070161"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38361-9"},{"key":"e_1_2_7_7_2","first-page":"1447","volume-title":"Physiology, Biochemistry, and Molecular Biology of the Skin","author":"Shaw J E","year":"1991"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371727"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470233"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb15121.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.6.875"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00657.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237545"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.5"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22534.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701138"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00540.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00016-6"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.605"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.123236"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2009.00899.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2009.00899.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:16:25Z","timestamp":1697066185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2009.00899.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,19]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1111\/j.1600-0625.2009.00899.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2009.00899.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,19]]}}}