{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T02:43:42Z","timestamp":1776393822139,"version":"3.51.2"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T00:00:00Z","timestamp":1264377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>Please cite this paper as: N<\/jats:italic>\u2010acetylcysteine inhibits chromium hypersensitivity in coadjuvant chromium\u2010sensitized albino guinea pigs by suppressing the effects of reactive oxygen species. Experimental Dermatology 2010;<jats:bold>19<\/jats:bold>: e191\u2013e200.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>Chromium hypersensitivity is an important issue in occupational skin disease. When hexavalent chromium enters the cell, it can be reduced to trivalent chromium, resulting in the formation of reactive oxygen species (ROS). ROS are considered to play an important role in the progression of allergic contact dermatitis.<jats:italic>N<\/jats:italic>\u2010acetylcysteine (NAC) could increase glutathione levels in the skin and act as an antioxidant.<\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold>We attempted to demonstrate that NAC could inhibit chromium hypersensitivity in a coadjuvant chromium\u2010sensitized albino guinea pig model by counteracting the formation of ROS.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>We utilized a coadjuvant chromium\u2010sensitized albino guinea pig model to evaluate both the severity of the skin reaction by intradermal and epicutaneous elicitation tests and the sensitization rate of chromium hypersensitivity in NAC\u2010treated and NAC\u2010untreated albino guinea pigs (GP). Furthermore, three ROS parameters, including H<jats:sub>2<\/jats:sub>O<jats:sub>2,<\/jats:sub>malondialdehyde (MDA) levels in the skin and the oxygen radical absorbance capacity (ORAC) in plasma, were analyzed in NAC\u2010treated and NAC\u2010untreated coadjuvant chromium\u2010sensitized albino GP.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>The severity of the skin reaction in the intradermal and epicutaneous elicitation test significantly diminished when the albino GP were treated with a dose of 1200\u2003mg\/kg\/day of NAC. This dose also significantly decreased the sensitization rate of chromium hypersensitivity. In addition, treatment with 1200\u2003mg\/kg\/day of NAC significantly reduced the H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>and MDA levels in the skin and significantly increased the ORAC in the plasma of albino GP. Therefore, NAC could be a potential chemopreventative agent to prevent the progression of chromium hypersensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0625.2009.01045.x","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T10:45:15Z","timestamp":1264416315000},"source":"Crossref","is-referenced-by-count":21,"title":["<i>N<\/i>\u2010acetylcysteine inhibits chromium hypersensitivity in coadjuvant chromium\u2010sensitized albino guinea pigs by suppressing the effects of reactive oxygen species"],"prefix":"10.1111","volume":"19","author":[{"given":"Bour\u2010Jr","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamm\u2010Min","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Hsiung","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Jan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500534032"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","unstructured":"Burrows D.Adverse chromate reactions on the Skin. 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