{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:45:07Z","timestamp":1790246707915,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>\n                    <jats:italic>Please cite this paper as:<\/jats:italic>\n                    Anti\u2010inflammatory effects of the GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor agonist baclofen in allergic contact dermatitis. Experimental Dermatology 2010; 19: 661\u2013666.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Abstract:\u2002<\/jats:bold>\n                    The gamma amino butyric acid B (GABA\n                    <jats:sub>B<\/jats:sub>\n                    ) receptor is a G protein\u2010coupled receptor (GPCR) involved in synaptic transmission. Recent data indicate it to be also expressed on immune cells, along with chemokine receptors, which are also GPCRs. As GPCRs can undergo heterologous desensitization, we have examined the ability of baclofen, a GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor selective agonist, to interfere with the function of pro\u2010inflammatory chemokine receptors known to be upregulated in cutaneous inflammation.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , baclofen reduces chemotaxis of human peripheral blood mononuclear cells towards CCL2, CCL5, CXCL10, CXCL2 and CX3CL1 in a dose\u2010dependant manner. Protein kinase C inhibitors calphostin C and G0 6976 could reverse this effect, pointing towards the involvement of both calcium\u2010dependent and \u2010independent protein kinase C in baclofen\u2010induced inhibition of chemokine receptors. In an\n                    <jats:italic>in vivo<\/jats:italic>\n                    model of contact hypersensitivity in C57BL\/6 mice, intraperitoneal injection of baclofen markedly alleviated signs of inflammation as well as recruitment of neutrophils, monocytes and lymphocytes into the skin. This study demonstrates a new role for the GABA\n                    <jats:sub>B<\/jats:sub>\n                    receptor in inflammation, making it a potential new therapeutic target to treat inflammatory skin diseases.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0625.2010.01076.x","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T06:38:15Z","timestamp":1267079895000},"page":"661-666","source":"Crossref","is-referenced-by-count":59,"title":["Anti\u2010inflammatory effects of the GABA\n                    <sub>B<\/sub>\n                    receptor agonist baclofen in allergic contact dermatitis"],"prefix":"10.1111","volume":"19","author":[{"given":"Beatrice","family":"Duthey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Boehncke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Pfeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Henning","family":"Boehncke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052723"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.11.001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.7.3267"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00007-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.2.317"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0248"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg002"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01383-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/400_2007_038"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5298"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.7242"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-157"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1619"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6027"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.02.008"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300430200"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.003205"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041320"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)00039-1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12563.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00630.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.03.001"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2010.01076.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2010.01076.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:08:18Z","timestamp":1698772098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2010.01076.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,14]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1111\/j.1600-0625.2010.01076.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2010.01076.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,14]]}}}