{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:22:40Z","timestamp":1790227360389,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T00:00:00Z","timestamp":1283212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p> <jats:italic>Please cite this paper as:<\/jats:italic> Protective effects of platinum nanoparticles against UV\u2010light\u2010induced epidermal inflammation. Experimental Dermatology 2010; <jats:bold>19<\/jats:bold>: 1000\u20131006.<\/jats:p><jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Intracellular reactive oxygen species (ROS) and apoptosis play important roles in the ultraviolet (UV)\u2010induced inflammatory responses in the skin. Metal nanoparticles have been developed to increase the catalytic activity of metals, which is because of the large surface area of smaller particles. Platinum nanoparticles (nano\u2010Pt) protected by poly acrylic acid were manufactured by reduction with ethanol. A marked increase in ROS production was observed in UV\u2010treated HaCaT keratinocytes cell lines, while a decrease in ROS production was observed in nano\u2010Pt\u2010treated cells. Pretreatment of the cells with nano\u2010Pt also caused a significant inhibition of UVB\u2010 and UVC\u2010induced apoptosis. Furthermore, we found that mice treated with nano\u2010Pt gel prior to UV irradiation showed significant inhibition of UVB\u2010induced inflammation and UVA\u2010induced photoallergy compared to UV\u2010irradiated control mice. These results suggest that nano\u2010Pt effectively protects against UV\u2010induced inflammation by decreasing ROS production and inhibiting apoptosis in keratinocytes.<\/jats:p>","DOI":"10.1111\/j.1600-0625.2010.01128.x","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T21:02:54Z","timestamp":1283288574000},"page":"1000-1006","source":"Crossref","is-referenced-by-count":80,"title":["Protective effects of platinum nanoparticles against UV\u2010light\u2010induced epidermal inflammation"],"prefix":"10.1111","volume":"19","author":[{"given":"Yoko","family":"Yoshihisa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riichiro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusei","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00210.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00150-1"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.09.013"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2004.07.009"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300841"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00259-2"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2006.01.006"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760601169679"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.3.761"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100300821"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.4049\/jimmunol.139.10.3199","article-title":"Gene induction by gamma\u2010irradiation leads to DNA fragmentation in lymphocytes","volume":"139","author":"Sellins K S","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-0807-5"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.10.064"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22227.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.4049\/jimmunol.160.8.3719","article-title":"Cross\u2010reactivity in murine fluoroquinolone photoallergy: exclusive usage of TCR Vbeta13 by immune T cells that recognize fluoroquinolone\u2010photomodified cells","volume":"160","author":"Tokura Y","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/1071576042000191754"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.08.019"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2002.00159.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq041"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.12.015"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.02.011"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.248"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.09.008"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00367.x"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405781200"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406626200"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4775"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00683.x"},{"key":"e_1_2_8_30_2","first-page":"1299","article-title":"Tropospheric ozone: an emerging environmental stress to skin","volume":"378","author":"Thiele J J","year":"1997","journal-title":"Biol Chem"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(98)00026-7"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0625.2010.01128.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0625.2010.01128.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T19:39:22Z","timestamp":1698781162000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0625.2010.01128.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,31]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1600-0625.2010.01128.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0625.2010.01128.x","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,31]]}}}